Aquired Radioresistance of Tumour Cells
| Autor: | S. B. Balmukhanov, T. S. Kleinbock, M. L. Yefimov |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Mitosis
In Vitro Techniques Polyploidy Mice Immune system In vivo Radioresistance medicine Animals Radiation Genetics Neoplasm Histidine Sulfhydryl Compounds Irradiation Carcinoma Ehrlich Tumor Multidisciplinary biology Histocytochemistry DNA Neoplasm medicine.disease In vitro Catalase Immunology biology.protein Cancer research |
| Zdroj: | Nature. 216:709-711 |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | RADIORESISTANCE of tumours, which appears as a result of repeated irradiation, was described in 1904 by Lassueur1. Certain characteristics were later examined: tumour ploidy2–6; the state of the mitochondria7 and ribosome8; the content of sulphydryl groups9,10; the capacity for anaerobic glycolysis11; catalase activity12; and changes in the immune relationships between tumour and organism13. The mechanism of the enhancement of tumour radioresistance, however, remains unknown. In experiments with Ehrlich ascites tumours in mice we have obtained radioresistant strains. This was achieved by intraperitoneal reinoculation preceded by irradiation of the tumour with 300 r. in vivo for 3 consecutive days and a single dose of 1,000 r. in vitro. We made between 50 and 120 passages in these conditions of repeated irradiation. The difference in radiation response of rhythmically irradiated and initial strains of Ehrlich tumour was determined after check-up irradiation with 1,000–3,000 r. |
| Databáze: | OpenAIRE |
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