Iron Store of Pregnant Women with Hemoglobin SS and SC in Benin City
| Autor: | Benedict N Ogbimi, Alfred E. Ehigiegba |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pediatrics
medicine.medical_specialty Pregnancy biology medicine.diagnostic_test Anemia Obstetrics business.industry Benin City iron status pregnancy sickle-cell hemoglobin medicine.disease Ferritin Statistical significance Personal computer medicine biology.protein Serum iron Hemoglobin business Mean corpuscular volume |
| Zdroj: | Journal of Basic and Clinical Reproductive Sciences; Vol 1, No 1-2 (2012); 38-43 |
| ISSN: | 2278-960X 2320-2041 |
| Popis: | Background: Anemia in pregnancy is common and morbidity is increased in the presence of sickle cell disease. There has been conflicting argument concerning routine iron replacement. However few, studies in Nigeria have comprehensively evaluated the iron status of these women. Objective: The study was carried out to determine the iron stores status of pregnant women with hemoglobin (Hb) Sickle cell S or Sickle cell C using the serum assay. C-reactive protein (CRP) was also assayed to rule out the effect of inflammation / infection on the serum level of ferritin.Materials and Methods: This was a prospective longitudinal study conducted at the University of Benin Teaching Hospital (UBTH), Benin City, over a period of eight months (from April 2011 to December 2011). The patients for the study were identified using the booking investigation results in the antenatal clinic records. Only those clinically stable pregnant women, in a healthy state, participated in this study.The hematological indices, serum ferritin assay, and the CRP were determined in both test (Hb SS / SC) and control (Hb AA) pregnant women. The data obtained were fed into a personal computer (PC) and analyzed using the Statistical Package for Social Sciences (SPSS) software version 16 for Windows. Categorical data were expressed as percentages and compared using the Chi-squared test, whereas, numerical data were expressed as mean (SD) and compared using the Student’s t-test. The level of significance was set at P≤0.05.Results: A total of 23 Hb SS / SC pregnant women formed the test group. They were recruited for the study from the Sickle-Cell Center (attached to the Central Hospital, Benin City, the UBTH). The mean age, educational status, and the social class of both the test group and the control group were comparable. There was a significant difference in the mean hemoglobin concentration between the test group and control group, both at 16–20 weeks and 28 – 32 weeks of gestation (P |
| Databáze: | OpenAIRE |
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