Improvement of left ventricular function after percutaneous coronary intervention in patients with stable coronary artery disease and preserved ejection fraction: Impact of diabetes mellitus
| Autor: | Bronisław Bednarz, Beata Zaborska, Paweł Maciejewski, Malgorzata Sikora-Frac, Andrzej Budaj |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Coronary Artery Disease Clinical Cardiology Ventricular Function Left Coronary artery disease Ventricular Dysfunction Left left ventricular function Diabetes mellitus Internal medicine Bayesian multivariate linear regression Humans echocardiography Medicine In patient cardiovascular diseases Ejection fraction business.industry percutaneous coronary intervention Coronary Stenosis Percutaneous coronary intervention Stroke Volume General Medicine medicine.disease Confidence interval diabetes mellitus Conventional PCI Cardiology Original Article Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiology Journal |
| ISSN: | 1898-018X 1897-5593 |
| DOI: | 10.5603/cj.a2019.0066 |
| Popis: | Background: Many patients with stable coronary artery disease (CAD) have no visual segmental wall motion abnormalities and a left ventricular (LV) ejection fraction (LVEF) ≥ 50% at rest despite significant coronary artery stenosis. Here, the aim was to determine the impact of percutaneous coronary intervention (PCI) on LV function assessed by enhanced echocardiography in patients with stable CAD with or without diabetes mellitus type 2 and a preserved LVEF. Methods: Sixty-six consecutive patients with CAD and LVEF ≥ 50%, admitted to the hospital for planned coronary angiography, were prospectively assessed. PCI was performed for coronary artery stenosis > 70%. CAD extent was assessed using SYNTAX and EXTENT scores. To assess LV function, LVEF, global longitudinal strain (GLS), and LV peak systolic myocardial velocity (S’) were measured and Tei index was calculated before and 3 months after PCI. Results: Before PCI, LVEF, GLS, and Tei index were significantly worse in diabetic patients. LV functional indices improved significantly after PCI in all patients (p < 0.001). Multivariate linear regression analyses were performed to evaluate the impact of selected factors on LV function after PCI expressed as changes (Δ) of LVEF, GLS, S’, and Tei index. LV function improvement expressed as ΔGLS was associated only with SYNTAX score. Higher SYNTAX scores were related to greater GLS improvement (β = 0.003, 95% confidence interval: 0.0004–0.005; p = 0.02). Conclusions: Percutaneous coronary intervention significantly improved LV function in diabetic and non-diabetic CAD patients with preserved LVEF. Enhanced echocardiography allowed an assessment of subtle changes in LV function. |
| Databáze: | OpenAIRE |
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