Prostate health index and prostate cancer gene 3 score but not percent-free Prostate Specific Antigen have a predictive role in differentiating histological prostatitis from PCa and other nonneoplastic lesions (BPH and HG-PIN) at repeat biopsy
| Autor: | Cristian Fiori, Enrico Bollito, A. Sottile, Susanna Cappia, Francesco Porpiglia, Roberto Mario Scarpa, Stefano De Luca, Roberto Passera, D.F. Randone |
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| Rok vydání: | 2015 |
| Předmět: |
PCA3
Male medicine.medical_specialty Urology Population Prostatic Hyperplasia Prostatitis urologic and male genital diseases Diagnosis Differential Prostate cancer Prostate Antigens Neoplasm Biopsy medicine Biomarkers Tumor Humans Prospective Studies education Aged Aged 80 and over education.field_of_study medicine.diagnostic_test business.industry Prostatic Neoplasms Middle Aged Prostate-Specific Antigen medicine.disease Percent Free Prostate-Specific Antigen Prostate-specific antigen medicine.anatomical_structure Oncology business |
| Zdroj: | Urologic oncology. 33(10) |
| ISSN: | 1873-2496 |
| Popis: | Objective To determine if prostate health index (PHI), prostate cancer antigen gene 3 (PCA3) score, and percentage of free prostate-specific antigen (%fPSA) may be used to differentiate asymptomatic acute and chronic prostatitis from prostate cancer (PCa), benign prostatic hyperplasia (BPH), and high-grade prostate intraepithelial neoplasia (HG-PIN) in patients with elevated PSA levels and negative findings on digital rectal examination at repeat biopsy (re-Bx). Patients and methods In this prospective study, 252 patients were enrolled, undergoing PHI, PCA3 score, and %fPSA assessments before re-Bx. We used 3 multivariate logistic regression models to test the PHI, PCA3 score, and %fPSA as risk factors for prostatitis vs. PCa, vs. BPH, and vs. HG-PIN. All the analyses were performed for the whole patient cohort and for the “gray zone” of PSA (4–10 ng/ml) cohort (171 individuals). Results Of the 252 patients, 43 (17.1%) had diagnosis of PCa. The median PHI was significantly different between men with a negative biopsy and those with a positive biopsy (34.9 vs. 48.1, P |
| Databáze: | OpenAIRE |
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