Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits
| Autor: | Mary E. Coussons-Read, Lena Brundin, Patrick Heilman, Emil F. Coccaro, Matthew N. Hill |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Kynurenine pathway Endocrinology Diabetes and Metabolism media_common.quotation_subject Arachidonic Acids Personality Disorders Article Glycerides Tridimensional Personality Questionnaire Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Humans Medicine Personality Picolinic Acids Receptors Cannabinoid Kynurenine Biological Psychiatry media_common Inflammation Interleukin-6 Endocrine and Autonomic Systems business.industry Novelty seeking Middle Aged medicine.disease Anxiety Disorders Neuroticism Personality disorders Eysenck Personality Questionnaire 030227 psychiatry Psychiatry and Mental health Reward dependence Female business 030217 neurology & neurosurgery Endocannabinoids Signal Transduction Clinical psychology |
| Zdroj: | Psychoneuroendocrinology |
| ISSN: | 0306-4530 |
| Popis: | Background Kynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these molecules is unknown. The role of these immunobiological mediators in emotionality and personality traits is not previously characterized. Methods Interleukin-6 (IL-6), 2-arachidonoylglycerol (2-AG) and picolinic acid (PIC) were measured in the plasma of physically healthy individuals who had history of mood, anxiety, and personality disorders (n = 96) or who had no history of any psychiatric disorder (n = 56) by DSM-5 Criteria. Dimensional assessments of personality were performed using the Eysenck Personality Questionnaire (EPQ) and the Tridimensional Personality Questionnaire (TPQ). Results Plasma IL-6 levels were significantly associated with plasma 2-AG levels and plasma PIC levels across all subjects. PIC levels were also negatively associated with 2-AG levels across all subjects, independent of IL-6 levels. In our analysis of the biological determinants of personality factors, we identified significant associations between IL-6 and novelty seeking assessment, and between PIC and neuroticism assessment. Conclusions These data provide evidence of a biological link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits. |
| Databáze: | OpenAIRE |
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