Age-Related Atrophy and Compensatory Neural Networks in Reading Comprehension
| Autor: | B. Blair Braden, Marwan N. Sabbagh, Corianne Rogalsky, Megan C. Fitzhugh, Leslie C. Baxter |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Aging Adolescent Article Age-Related Atrophy Young Adult Atrophy Task-positive network medicine Humans Attention Aged Language Cortical atrophy Aged 80 and over Cerebral Cortex medicine.diagnostic_test Artificial neural network General Neuroscience Middle Aged medicine.disease Comprehension Psychiatry and Mental health Clinical Psychology Reading Reading comprehension Female Neurology (clinical) Nerve Net Psychology Functional magnetic resonance imaging Neuroscience |
| Zdroj: | Journal of the International Neuropsychological Society. 25:569-582 |
| ISSN: | 1469-7661 1355-6177 |
| DOI: | 10.1017/s1355617719000274 |
| Popis: | Objectives: Despite changes to brain integrity with aging, some functions like basic language processes remain remarkably preserved. One theory for the maintenance of function in light of age-related brain atrophy is the engagement of compensatory brain networks. This study examined age-related changes in the neural networks recruited for simple language comprehension. Methods: Sixty-five adults (native English-speaking, right-handed, and cognitively normal) aged 17–85 years underwent a functional magnetic resonance imaging (fMRI) reading paradigm and structural scanning. The fMRI data were analyzed using independent component analysis to derive brain networks associated with reading comprehension. Results: Two typical frontotemporal language networks were identified, and these networks remained relatively stable across the wide age range. In contrast, three attention-related networks showed increased activation with increasing age. Furthermore, the increased recruitment of a dorsal attention network was negatively correlated to gray matter thickness in temporal regions, whereas an anterior frontoparietal network was positively correlated to gray matter thickness in insular regions. Conclusions: We found evidence that older adults can exert increased effort and recruit additional attentional resources to maintain their reading abilities in light of increased cortical atrophy. |
| Databáze: | OpenAIRE |
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