Sex Differences in Outcomes Following Endovascular Treatment for Symptomatic Peripheral Artery Disease: An Analysis From the K- VIS ELLA Registry
| Autor: | Yoon Seok Koh, Taek Kyu Park, Cheol Woong Yu, Pil-Ki Min, Donghoon Choi, Chang Hwan Yoon, Jihoon Kim, Ki Hong Choi, Seung-Hyuk Choi, In-Ho Chae, Young Guk Ko, Jae-Hwan Lee |
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| Rok vydání: | 2019 |
| Předmět: |
Male
endovascular treatment medicine.medical_specialty Time Factors Arterial disease Disease Patient assessment peripheral artery disease outcomes percutaneous transluminal angioplasty Vascular Medicine Disease-Free Survival Peripheral Arterial Disease Sex Factors Risk Factors Republic of Korea Medicine Humans sex Registries Endovascular treatment Sex Distribution Aged Retrospective Studies Original Research Stenosis business.industry Incidence Revascularization Endovascular Procedures Surgery Survival Rate Treatment Outcome Lower Extremity Peripheral Vascular Disease Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| Popis: | Background With advances in peripheral artery disease ( PAD ) treatments such as endovascular treatment ( EVT ), personalized patient assessment is important. Data on sex differences in clinical outcome for PAD patients undergoing EVT have been limited, and studies have produced conflicting results. This study sought to compare midterm clinical outcomes between women and men in a large population of patients with PAD undergoing EVT . Methods and Results The K‐ VIS ELLA (Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Disease) registry is a nationwide, multicenter, observational study that includes 3073 PAD patients undergoing EVT . The study population was divided into men (n=2523) and women (n=550). The primary outcome was a composite of death, myocardial infarction, and major amputation; the secondary outcome included major adverse limb events. Women had more comorbidities and more severe and complex target lesions than men. Women showed higher rates of death, myocardial infarction, or major amputation than men (14.8% versus 9.8%, adjusted hazard ratio 1.350, 95% CI 1.017‐1.792, P =0.038), and higher rates of major adverse limb events (19.9% versus 14.5%, adjusted hazard ratio 1.301, 95% CI 1.014‐1.670, P =0.039) and procedural complications (10.2% versus 5.9%, P CI 1.421‐3.068, P CI 0.800‐1.694, P =0.426). A significant interaction ( P =0.035) between patient presentation and outcome was observed. Conclusions In a large population of patients with PAD undergoing EVT , women had higher rates of death, myocardial infarction, or major amputation than men and higher rates of complex lesions, procedural complications, and limb‐specific adverse events. |
| Databáze: | OpenAIRE |
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