Long-Term Outcome and Rejection After Allogeneic Uterus Transplantation in Cynomolgus Macaques

Autor: Ikuo Kawamoto, Iori Kisu, Kazumasa Ogasawara, Yojiro Kato, Katsura Emoto, Daisuke Aoki, Masataka Adachi, Takashi Shiina, Chizuru Iwatani, Hirohito Ishigaki, Hideaki Obara, Hiroyuki Urano, Yohei Masugi, Masatsugu Ema, Yusuke Matoba, Hideaki Tsuchiya, Yohei Yamada, Kouji Banno, Kentaro Matsubara, Takahiro Nakagawa, Iori Itagaki, Takako Sasamura, Yoko Saiki, Kenshi Nakagawa
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Clinical Medicine
Volume 8
Issue 10
Journal of Clinical Medicine, Vol 8, Iss 10, p 1572 (2019)
ISSN: 2077-0383
DOI: 10.3390/jcm8101572
Popis: Uterus transplantation (UTx) is an option for women with uterine factor infertility to have a child, but is still in the experimental stage. Therefore, allogeneic animal models of UTx are required for resolution of clinical issues. In this study, long-term outcomes were evaluated in four recipients (cases 1&ndash
4) after allogeneic UTx in cynomolgus macaques. Immunosuppression with antithymocyte globulin induction and a triple maintenance regimen was used. Postoperative ultrasonography and biopsy of the transplanted uterus and immunoserological examinations were performed. All four recipients survived for >
3 months after surgery, but continuous menstruation did not resume, although temporary menstruation occurred (cases 1 and 2). All animals were euthanized due to irreversible rejection and no uterine blood flow (cases 1, 2 and 4) and post-transplant lymphoproliferative disorder (case 3). Donor-specific antibodies against MHC class I and II were detected in cases 1, 2 and 4, but not in case 3. Peripheral lymphocyte counts tended to elevate for CD3+, CD20+ and NK cells in conjunction with uterine rejection, and all animals had elevated stimulation indexes of mixed lymphocyte reaction after surgery. Establishment of allogeneic UTx in cynomolgus macaque requires further exploration of immunosuppression, but the clinicopathological features of uterine rejection are useful for development of human UTx.
Databáze: OpenAIRE
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