Sex moderates the effects of experimentally induced musculoskeletal pain on alcohol demand in healthy drinkers
| Autor: | Jesse Dallery, Molly A.B. Anderson, Erin G. Ferguson, Meryl J. Alappattu, Darya Vitus, Bethany Stennett, Jeff Boissoneault, Michael E. Robinson |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Musculoskeletal pain medicine.medical_specialty Time Factors Alcohol Drinking Alcohol Toxicology Article Pain rating 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Musculoskeletal Pain Delayed onset muscle soreness Epidemiology medicine Humans Pharmacology (medical) 030212 general & internal medicine Muscle Skeletal Exercise Pain Measurement Pharmacology Ethanol business.industry Repeated measures design Psychiatry and Mental health chemistry Eccentric exercise Physical therapy Female medicine.symptom Hazardous drinking business 030217 neurology & neurosurgery |
| Zdroj: | Drug Alcohol Depend |
| ISSN: | 0376-8716 |
| Popis: | Background Pain may serve as an antecedent for alcohol use, increasing risk for hazardous drinking and associated consequences. Delayed onset muscle soreness (DOMS) induction produces clinically relevant but time-limited musculoskeletal pain. This study was conducted to determine whether DOMS induction on the dominant elbow flexors influenced alcohol demand using the Alcohol Purchase Task (APT). We hypothesized DOMS would increase alcohol demand relative to a sham control. Based on existing studies of pain self-medication, we expected DOMS-related increases in alcohol demand would be greatest in men. Methods Participants (N = 53; 57 % women) were randomly assigned to a DOMS (eccentric exercise) or sham condition (concentric exercise). Participants completed the APT pre-exercise and 48 -hs post-exercise. Repeated measures GLM was used to characterize group by sex by time interactions on APT indices, including intensity, breakpoint, essential value (EV), Omax, and Pmax. Results The DOMS procedure significantly increased pain ratings at the elbow flexors. Men had significantly higher demand intensity than women across groups and time points. Significant interactive effects were detected for breakpoint and EV. From pre- to post-test, breakpoint significantly increased in men in the DOMS group. However, breakpoint and EV significantly decreased in women in the DOMS group. Conclusions Increased alcohol demand in men in the DOMS group was consistent with epidemiological data suggesting men are at higher risk for self-medicating pain with alcohol than women. However, decreased demand in women was unexpected. Taken together, results indicate DOMS induction may be a useful means to characterize pain as an antecedent for alcohol use. |
| Databáze: | OpenAIRE |
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