The Natural Products Atlas 2.0: a database of microbially-derived natural products
| Autor: | Jeffrey A. van Santen, Alison H. Hughes, Roger G. Linington, Jeffrey D. Rudolf, David P. Fewer, Elisabeth M.-L. Janssen, Trevor N. Clark, Tyler A. Alsup, Claire H. Fergusson, Dasha Iskakova, Jonathan Parra, Katherine R. Duncan, Ella F. Poynton, Sylvia Soldatou, Caitlin A. McCadden, Emily McMann |
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| Přispěvatelé: | Department of Microbiology, Department of Food and Nutrition, Helsinki Institute of Sustainability Science (HELSUS), Microbial Natural Products |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
RM
Databases Factual AcademicSubjects/SCI00010 Dashboard (business) Ontology (information science) Biology computer.software_genre 01 natural sciences Natural (archaeology) Field (computer science) QA76 03 medical and health sciences User-Computer Interface User experience design Genetics Database Issue Humans 030304 developmental biology 0303 health sciences Biological Products Application programming interface Database Bacteria Host Microbial Interactions 010405 organic chemistry business.industry Fungi Classification 0104 chemical sciences 1182 Biochemistry cell and molecular biology Natural Products Chemistry business ACCESS Classifier (UML) computer Software |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | Within the natural products field there is an increasing emphasis on the study of compounds from microbial sources. This has been fuelled by interest in the central role that microorganisms play in mediating both interspecies interactions and host-microbe relationships. To support the study of natural products chemistry produced by microorganisms we released the Natural Products Atlas, a database of known microbial natural products structures, in 2019. This paper reports the release of a new version of the database which includes a full RESTful application programming interface (API), a new website framework, and an expanded database that includes 8128 new compounds, bringing the total to 32 552. In addition to these structural and content changes we have added full taxonomic descriptions for all microbial taxa and have added chemical ontology terms from both NP Classifier and ClassyFire. We have also performed manual curation to review all entries with incomplete configurational assignments and have integrated data from external resources, including CyanoMetDB. Finally, we have improved the user experience by updating the Overview dashboard and creating a dashboard for taxonomic origin. The database can be accessed via the new interactive website at https://www.npatlas.org. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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