Humoral and Renal Response to Acute Volume Loading in Patients with Essential Hypertension
| Autor: | Srámková J, Dvoráková J, Karel Horký, Gregorová I |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Hypertension Renal Endocrinology Diabetes and Metabolism medicine.medical_treatment Natriuresis Kidney Essential hypertension Plasma renin activity Renin-Angiotensin System chemistry.chemical_compound Endocrinology Atrial natriuretic peptide Internal medicine Renin Renin–angiotensin system Internal Medicine medicine Humans Aldosterone Sodium Hemodynamics General Medicine Middle Aged Creatine medicine.disease chemistry Renal physiology Potassium Diuretic Hypervolemia Atrial Natriuretic Factor |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 95:361-368 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1210977 |
| Popis: | The effect of acute volume expansion (2 liters of saline solution in 2 h) on plasma concentrations of atrial natriuretic factor (ANF), plasma aldosterone concentration (PAC), plasma renin activity (PRA) and their relationship to the renal excretion of urine, sodium and potassium were studied in 6 control subjects and 7 patients with essential hypertension (EH) WHO stage I. Saline infusion provoked comparable rise in plasma ANF in both groups (from 2.98 +/- 0.45 to 12.36 +/- 1.74 pmol/l in the control subjects and from 3.80 +/- 0.72 to 15.78 +/- 2.06 pmol/l in EH patients), significant drop in PRA (from 0.915 +/- 0.419 to 0.256 +/- 0.127 nmol/l/h in controls and from 1.711 +/- 0.324 to 0.714 +/- 0.128 nmol/l/h in EH) and in PAC (from 0.30 +/- 0.07 to 0.14 +/- 0.03 nmol/l in control subjects and from 0.53 +/- 0.13 to 0.24 +/- 0.07 nmol/l in EH). The increase of plasma ANF concentrations after volume expansion might be involved in the suppression of PRA and PAC found after this stimulus. Similar increase in plasma ANF after saline infusion in both groups was associated with significantly greater urine and sodium excretion in EH than in controls. From these results it may be suggested that the acute volume expansion during saline infusion evokes a comparable release of ANF into circulation in both EH patients and controls. In EH patients, however, the similar rise in ANF is accompanied by a more pronounced diuretic and natriuretic response. This exaggerated natriuresis after acute volume and sodium loading cannot be explained solely by a rise in ANF.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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