Hyperglycemia Without Hyperinsulinemia Produces Both Sympathetic Neural Activation and Vasodilation in Normal Humans
| Autor: | Erling A. Anderson, Martin Hausberg, Robert P. Hoffman, Christine A. Sinkey |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Sympathetic nervous system Sympathetic Nervous System Endocrinology Diabetes and Metabolism medicine.medical_treatment Vasodilation Octreotide Endocrinology Reference Values Internal medicine Internal Medicine medicine Hyperinsulinemia Humans Insulin Mannitol Infusions Intravenous Muscle Skeletal Saline Neurons Glucose tolerance test medicine.diagnostic_test business.industry medicine.disease Forearm Glucose medicine.anatomical_structure Hyperglycemia Vascular resistance Female Vascular Resistance business medicine.drug |
| Zdroj: | Journal of Diabetes and its Complications. 13:17-22 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/s1056-8727(98)00019-1 |
| Popis: | To explore the effects of the acute induction of hyperglycemia on sympathetic activity and vascular function we studied eight normal control subjects (28 +/- 3 years of age). Muscle sympathetic nerve activity (MSNA) and forearm vascular resistance (FVR) were measured before (5.4 +/- 0.2 mmol/L) and during systemic infusion of 20% dextrose with octreotide (250 microg/h) and low dose insulin (4 mU x m(-2) x min(-1)) with 60 min of hyperglycemia (venous plasma glucose, 12.5 +/- 0.6 mmol/L). To control for the effects of hyperosmolarity and volume infusion subjects returned for two control studies with equal volume 20% mannitol and 0.2% saline infusions instead of dextrose infusion. The increase in MSNA during hyperglycemia (178 +/- 48 units) was significantly greater than the increase during mannitol (69 +/- 46 units, p < 0.001) or during 0.2% saline (28 +/- 28 units, p < 0.001). The decreases in FVR after 60 min of hyperglycemia (20 +/- 4 units, p = 0.002) and mannitol (13 +/- 4 units, p = 0.033) were significantly greater than the decrease during saline (0.1 +/- 4 units). The changes in FVR during hyperglycemia and mannitol did not differ. Acute hyperglycemia causes sympathoexcitation and peripheral vasodilation. The vascular effect may be mediated by increased osmolar load. |
| Databáze: | OpenAIRE |
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