Opicapone for the treatment of Parkinson’s disease
| Autor: | Rodrigues, Filipe Brogueira, Ferreira, Joaquim J |
|---|---|
| Přispěvatelé: | Repositório da Universidade de Lisboa |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Parkinson's disease Dopamine Disease Catechol O-Methyltransferase COMT inhibitor Opicapone Antiparkinson Agents 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Humans Medicine Pharmacology (medical) Pharmacology Oxadiazoles business.industry Disease progression Catechol O-Methyltransferase Inhibitors Treatment options Parkinson Disease General Medicine medicine.disease Motor fluctuations 030104 developmental biology chemistry Anesthesia Parkinson’s disease Disease Progression business 030217 neurology & neurosurgery |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 1744-7666 1465-6566 |
| DOI: | 10.1080/14656566.2017.1294683 |
| Popis: | © 2017 Informa UK Limited, trading as Taylor & Francis Group Parkinson's disease (PD) is a progressive neurodegenerative disease. The currently available treatment options only have a symptomatic effect. With disease progression almost all antiparkinsonian pharmacological classes are tried, but the gold standard of pharmacological management is still L-dopa. Various strategies can be used to raise the dopaminergic tone. Catechol-O-methyltransferase (COMT) inhibitors attain this goal by decreasing L-dopa peripheral metabolism. Areas covered: Opicapone (Ongentys®) is a new COMT inhibitor developed to fulfill the need for more potent, safer and longer acting COMT inhibitors. This review puts into context opicapone's indications, its chemical and preclinical data, the pharmacodynamics and pharmacokinetic characteristics, and the efficacy and safety results delivered by clinical trials. Expert opinion: Opicapone is an efficacious COMT inhibitor. Its proprieties make it adequate for a once-a-day oral dose regimen. It has proved to reduce the off-time and to increase the on-time without troublesome dyskinesias in PD patients with motor fluctuations. The reported adverse events suggest an overall safe and well-tolerated profile. The most common adverse events were dyskinesia, and there were no issues of concern for hepatotoxicity, severe diarrhoea or chromaturia. Further evidence is still needed to conclude how it compares with other drugs for the treatment of motor fluctuations. |
| Databáze: | OpenAIRE |
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