Lymphocytes Stimulated With Recombinant Human Interleukin-2: Relationship Between Motility Into Protein Matrix and In Vivo Localization in Normal and Neoplastic Tissues of Mice
| Autor: | Stuart Ratner |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Interleukin 2
Cancer Research Adoptive cell transfer Pathology medicine.medical_specialty Lymphocyte Fluorescent Antibody Technique Motility Biology Extracellular matrix Mice Cell Movement In vivo medicine Animals Lymphocytes Lung Cells Cultured Mice Inbred BALB C Immunization Passive Mammary Neoplasms Experimental Molecular biology Recombinant Proteins In vitro Extracellular Matrix medicine.anatomical_structure Oncology Interleukin-2 Collagen Gels Neoplasm Transplantation Type I collagen medicine.drug |
| Zdroj: | JNCI Journal of the National Cancer Institute. 82:612-616 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/82.7.612 |
| Popis: | Murine splenic lymphocytes nonspecifically stimulated with recombinant human interleukin-2 in vitro were fractionated according to their ability to migrate through type I collagen gel during a 24-hour period. After labeling with 111In and adoptive transfer into hosts of subcutaneous mammary tumors, motile fractions exhibited approximately twofold greater tumor localization and approximately twofold lower lung localization than nonmotile fractions. The results suggest that lymphocyte properties associated with motility through extracellular matrix also influence patterns of lymphocyte localization in vitro. It should be possible to identify these properties by comparative analysis of motile and nonmotile fractions obtained from various matrices. |
| Databáze: | OpenAIRE |
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