Intrauterine growth restriction, soluble fms-like tyrosine kinase-1 to placental growth factor ratio increase and preeclampsia
| Autor: | H. Boulanger, C. Largilliere, D. Drouin, G. Lefèvre |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Placental growth factor medicine.medical_specialty Intrauterine growth restriction Preeclampsia 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Internal medicine medicine Humans reproductive and urinary physiology Placenta Growth Factor Fetal Growth Retardation Vascular Endothelial Growth Factor Receptor-1 030219 obstetrics & reproductive medicine Cesarean Section business.industry Infant Newborn Obstetrics and Gynecology Placental disease medicine.disease female genital diseases and pregnancy complications Endocrinology Reproductive Medicine 030220 oncology & carcinogenesis Infant Small for Gestational Age embryonic structures Female business Tyrosine kinase Maternal Serum Screening Tests Soluble fms-like tyrosine kinase-1 |
| Zdroj: | Journal of Gynecology Obstetrics and Human Reproduction. 48:695-697 |
| ISSN: | 2468-7847 |
| DOI: | 10.1016/j.jogoh.2019.05.007 |
| Popis: | Background Intrauterine growth restriction (IUGR) and preeclampsia (PE) share common features such as ischemic placental disease but also differ in their clinical expression regarding maternal diseases. The reason why IUGRremains isolated in some cases yet is followed by clinical manifestations of PE in other cases remains unexplained. Case report A 40-year old woman, gravida two, para one, experienced early-onset IUGR with a significant increase in the ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) but, surprisingly, without any maternal clinical manifestations of PE. Conclusion IUGR and a significant increase in sFlt-1/PlGF ratio without PE raise the issue of a missing factor enabling IUGR, a significant increase in sFlt-1/PlGF ratio, and PE to be linked. Teaching points (1) Early-onset IUGR and a significant increase in sFlt-1/PlGF ratio do not necessarily mean the onset of PE. (2) Combining early-onset IUGR and a significant increase in sFlt-1/PlGF ratio without PE raises the question of an additional factor responsible for the onset of PE. |
| Databáze: | OpenAIRE |
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