Impairment of Lung Function During Adjuvant Oxaliplatin Treatment in Patients with Colorectal Cancer: A Prospective Trial
| Autor: | Maria L. Jöhnk, June A. Ejlersen, Nina Keldsen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Lung Diseases Male medicine.medical_specialty Organoplatinum Compounds Colorectal cancer Pulmonary toxicity Antineoplastic Agents Toxicology Gastroenterology Pulmonary function testing Cohort Studies 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Internal medicine medicine Humans Pharmacology (medical) Prospective Studies Prospective cohort study Aged Randomized Controlled Trials as Topic Pharmacology Aged 80 and over business.industry Middle Aged medicine.disease Surgery Oxaliplatin Treatment Outcome 030220 oncology & carcinogenesis Cohort 030211 gastroenterology & hepatology Female business Colorectal Neoplasms medicine.drug Cohort study |
| Zdroj: | Current drug safety. 11(3) |
| ISSN: | 2212-3911 |
| Popis: | Background: Forty-seven cases (38 men and 9 women) of pulmonary toxicity caused by oxaliplatin have previously been published, but the issue has not been investigated in a prospective setting. Our purpose was to assess how oxaliplatin affects the pulmonary function in colorectal cancer patients during adjuvant treatment. Material and Methods: Forty patients (median age 57.5 years, range 33-74) radically resected for colorectal cancer, underwent three pulmonary function tests during post-surgery adjuvant treatment with oxaliplatin. Results: Mean±sd haemoglobin corrected diffusion capacity (DLCOc) in the entire patient cohort were 7.65±2.24 at baseline, 7.11±2.11 during and 7.12±1.99 three months after oxaliplatin treatment (p=0.0002). The decrease was similar in men (n=22, p=0.02) and women (n=18, p=0.01), but most prominent in smokers (n=23, p=0.0005) and in patients exposed to occupational dust (n=21, p=0.0009). Besides a small decrease in the FEV1/FVC ratio (p=0.03), all other pulmonary parameters remained constant and no clinical signs of pulmonary failure were observed during the study period. Conclusion: A decline in DLCOc was detected in a majority of the examined patients, but none reported any clinical symptoms of pulmonary distress. The subtle decrease in DLCOc does not appear to be an isolated predictor of PT. Our data suggest that smoking and dust exposure might aggravate the effect of oxaliplatin on DLCOc. Routine pulmonary function test in patients treated with oxaliplatin is not recommended, but it is important to be aware of the early signs of pulmonary toxicity. |
| Databáze: | OpenAIRE |
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