Monoamine Compounds in Cerebrospinal Fluid of Healthy Subjects Punctured without Preceding Strict Bed Rest: A Pilot Study
| Autor: | Tove Gunnarsson, Thomas Eklundh, Conny Nordin |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Serotonin Dopamine medicine.medical_treatment Bed rest Spinal Puncture Methoxyhydroxyphenylglycol Norepinephrine chemistry.chemical_compound Lumbar Cerebrospinal fluid Reference Values medicine Humans Biological Psychiatry medicine.diagnostic_test Lumbar puncture 5-Hydroxyindoleacetic acid Homovanillic acid Tryptophan Homovanillic Acid Hydroxyindoleacetic Acid Psychiatry and Mental health Neuropsychology and Physiological Psychology Monoamine neurotransmitter chemistry Anesthesia 3 4-Dihydroxyphenylacetic Acid Tyrosine Female Psychology Bed Rest medicine.drug |
| Zdroj: | Neuropsychobiology. 43:5-10 |
| ISSN: | 1423-0224 0302-282X |
| DOI: | 10.1159/000054857 |
| Popis: | The interpretation of data on compounds in the lumbar cerebrospinal fluid (CSF) is limited by several confounding factors, e.g. motor activity for which strict bed rest prior to lumbar puncture is recommended for standardisation. Now we report data from 14 healthy males employing the standardised procedure except for the requirement of strict bed rest. The levels of serotonin, noradrenaline, 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid and 4-hydroxy-3-methoxyphenylglycol in the second CSF fraction (7–12 ml) were significantly higher than those in the first fraction (0–6 ml), indicating the presence of concentration gradients. 5-HIAA was negatively influenced by age and the neuraxis distance in the lying position and positively by atmospheric pressure. Storage time and atmospheric pressure contributed to the variance in dopamine. Both tyrosine, tryptophan and dopamine were linearly correlated with storage time. We also found a significant curvilinear correlation between tapping time and atmospheric pressure. On comparing with previous studies, the results support the notion that the issue of strict bed rest or not prior to lumbar puncture might have to be taken into consideration when interpreting lumbar monoamine CSF data. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|