Paediatric malignant melanoma in Ireland: A population study and review of the literature
| Autor: | Christine S. Quinlan, Michael Capra, Marlese Dempsey |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Skin Neoplasms Adolescent Disease Breslow Thickness 03 medical and health sciences 0302 clinical medicine Patient age Recurrence Risk Factors medicine Humans 030212 general & internal medicine Registries Neoplasm Metastasis Child Melanoma National data Neoplasm Staging Retrospective Studies business.industry Sentinel Lymph Node Biopsy Incidence Infant Margins of Excision medicine.disease Surgery Cancer registry Treatment Outcome 030220 oncology & carcinogenesis Child Preschool Lymphatic Metastasis Population study Disease characteristics Female business Ireland |
| Zdroj: | Journal of plastic, reconstructiveaesthetic surgery : JPRAS. 72(8) |
| ISSN: | 1878-0539 |
| Popis: | Summary Introduction Malignant melanoma is increasing in frequency worldwide; however, this disease is rare in children. As large-scale studies on paediatric melanoma are lacking, management is currently often based upon the understanding of the disease process in adults. The aim of this study was to characterise cases of paediatric melanoma diagnosed in the Republic of Ireland over a 21-year period. Methods This was a retrospective, multicentre study using national data provided by the National Cancer Registry of Ireland and individual practitioners. Results Twenty-four cases of melanoma treated in 11 different centres were included in the study. The median patient age at diagnosis was 15 years. The majority of cases arose on the limbs. The median Breslow thickness in patients of the pre-pubertal age group was 8.25 mm, while in children more than 13 years, it was 1.65 mm. Eight patients had disease recurrence and five patients died. Conclusion The diagnosis of melanoma remains rare in children. This study contributes to our current understanding of malignant melanoma in paediatric patients; however, further investigation of the disease characteristics in this group is necessary to achieve optimal management of these cases and therefore improve outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect