Kisspeptin and body weight homeostasis in relation to phenotypic features of polycystic ovary syndrome; metabolic regulation of reproduction

Autor: Radwa M. Al-sayed, Mohammed S. Yousef, Yasser S. Saraya, Nearmeen M. Rashad
Rok vydání: 2019
Předmět:
Adult
Blood Glucose
0301 basic medicine
endocrine system
medicine.medical_specialty
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Overweight
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Thinness
Internal medicine
Diabetes mellitus
Internal Medicine
Homeostasis
Humans
Medicine
Obesity
Glycemic
Glycated Hemoglobin
Kisspeptins
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
business.industry
Reproduction
Body Weight
nutritional and metabolic diseases
General Medicine
Anthropometry
Prognosis
medicine.disease
Polycystic ovary
Cross-Sectional Studies
030104 developmental biology
Endocrinology
Case-Control Studies
Female
Insulin Resistance
medicine.symptom
Underweight
business
Lipid profile
human activities
Body mass index
Biomarkers
Follow-Up Studies
Polycystic Ovary Syndrome
Zdroj: Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 13:2086-2092
ISSN: 1871-4021
DOI: 10.1016/j.dsx.2019.04.017
Popis: Background Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by a diverse collection of reproductive and metabolic abnormalities. kisspeptin (KISS) is novel peptides associated with regulation of metabolism, food intake, puberty and reproduction. The aim of the present study was to estimate KISS level in patients with PCOS, and to evaluate the possible relationship between KISS level with anthropometric measures as well as clinic-morphological features of PCOS. Materials and methods cross section control study enrolled 90 control group and 105 patients with PCOS and they were stratified according to their body mass index (BMI) to; underweight (n = 9, BMI ˂19), normal weight (n = 25, BMI = 19.1–25), over weight (n = 34,BMI = 25.1–30), obese grade I (n = 12, BMI = 30.1–35) , obese grade II (n = 13, BMI 35.1–40) and obese grade III (n = 12, BMI˃40).Circulating KISS levels were measured using ELISA. Results Our results revealed that, KISS levels were higher in PCOS patients compared to controls. Among PCOS group, there were significant lower level of KISS levels in underweight, overweight and obese compared to normal weight group. Even more importantly, KISS levels decreased with increasing of BMI as the following, grade I, grade II and grade III. Moreover, it was negatively correlated to anthropometric measures, glycemic, lipid profile and positively correlated the phenotype characteristics of PCOS. Linear regression test observed that hirsutism score, HOMA-IR and LH were the main predictors of KISS levels in PCOS. Conclusion: circulating KISS is an important regulator of body weight and reproduction especially in PCOS women.
Databáze: OpenAIRE
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