Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase i
| Autor: | Tatiana Y. Zakharian, Luigi Di Costanzo, David W. Christianson |
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| Přispěvatelé: | Zakharian, T. Y., DI COSTANZO, Luigi, Christianson, D. W. |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Models
Molecular Stereochemistry chemistry.chemical_element Crystal structure Manganese Crystallography X-Ray Biochemistry Article Metal Hydrolase Molecule Humans Physical and Theoretical Chemistry chemistry.chemical_classification biology Arginase Molecular Structure Organic Chemistry Active site Crystallography Enzyme Cross-Linking Reagents chemistry Metals visual_art biology.protein visual_art.visual_art_medium Epoxy Compounds Protein Binding |
| Popis: | The synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid is reported along with the X-ray crystal structure of its complex with human arginase I, revealing unique coordination interactions with two manganese ions in the enzyme active site. |
| Databáze: | OpenAIRE |
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