Adipocyte accumulation in corpus cavernosum: First clinical evidence and pathophysiological implications in erectile dysfunction
| Autor: | J. Vinay, C. Palma, Eduard Ruiz-Castañé, Joaquim Sarquella, J. Sanchez, Ferran Algaba, I. Gallegos |
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| Rok vydání: | 2017 |
| Předmět: |
endocrine system
medicine.medical_specialty Adipocyte accuMulation 030219 obstetrics & reproductive medicine business.industry Penile rigidity medicine.medical_treatment Adipocyte Accumulation Urology Penile prosthesis General Medicine medicine.disease 03 medical and health sciences Tunica albuginea (ovaries) 0302 clinical medicine Erectile dysfunction 030220 oncology & carcinogenesis Androgen ditruption Medicine Venous leakage business |
| Zdroj: | Actas Urologicas Espanolas r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 2173-5786 0210-4806 |
| Popis: | Objectives: Animal models have shown that erectile dysfunction is associated with adipocyte accumulation under tunica albuginea, which could be involved in venous leakage and loss of penile rigidity. In the current sudy, we compared the histology of the penile sub-albuginean region of drug-refractory erectile dysfunction patients undergoing penile prosthesis implantation with potent patients with Peyronie's disease undergoing curvature correction procedures. Materials and methods: Seventeen refractory erectile dysfunction patients and fourteen potent patients with Peyronie's disease were recruited. Sub-albuginean tissue samples were taken in each surgery. An expert uropathologist analysed each section. A bivariate analysis was performed. Multivariate logistic regression was used to calculate adjusted odds ratios; P value < .05 was considered significant. Results: Eleven patients (11/17) in the case group presented cavernous fat cell accumulation, while only one patient (1/14) in the control group presented this finding (P |
| Databáze: | OpenAIRE |
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