Family aggregation and risk factors in substance use disorders over three generations in a nation-wide study

Autor: Helle Jakobsen, Hans-Christoph Steinhausen, Povl Munk-Jørgensen
Přispěvatelé: University of Zurich
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Bipolar Disorder
Eating Disorders
Denmark
Social Sciences
lcsh:Medicine
Drug Abuse
0302 clinical medicine
Risk Factors
Medicine and Health Sciences
Odds Ratio
Psychology
Medicine
Public and Occupational Health
Depressive Disorder/complications
Personality Disorders/complications
Young adult
lcsh:Science
Depression (differential diagnoses)
Multidisciplinary
Depression
Drugs
10058 Department of Child and Adolescent Psychiatry
Anxiety Disorders
humanities
Substance abuse
Alcoholism
Eating disorders
Anxiety
Female
medicine.symptom
Research Article
Adult
medicine.medical_specialty
Adolescent
Substance-Related Disorders
Addiction
Neuropsychiatric Disorders
610 Medicine & health
1100 General Agricultural and Biological Sciences
Neuroses
Personality Disorders
behavioral disciplines and activities
03 medical and health sciences
Young Adult
Sex Factors
1300 General Biochemistry
Genetics and Molecular Biology
Mental Health and Psychiatry
mental disorders
Journal Article
Humans
Family
Bipolar disorder
Psychiatry
Anxiety Disorders/complications
Proportional Hazards Models
Pharmacology
Behavior
Depressive Disorder
1000 Multidisciplinary
Mood Disorders
Cannabinoids
business.industry
lcsh:R
Biology and Life Sciences
Odds ratio
medicine.disease
Personality disorders
Denmark/epidemiology
030227 psychiatry
Case-Control Studies
Schizophrenia
lcsh:Q
business
030217 neurology & neurosurgery
Substance-Related Disorders/complications
Zdroj: PLoS ONE, Vol 12, Iss 5, p e0177700 (2017)
Steinhausen, H-C, Jakobsen, H & Munk-Jørgensen, P 2017, ' Family aggregation and risk factors in substance use disorders over three generations in a nation-wide study ', PLOS ONE, vol. 12, no. 5, e0177700 . https://doi.org/10.1371/journal.pone.0177700
Steinhausen, H-C, Jakobsen, H & Munk-Jørgensen, P 2017, ' Family aggregation and risk factors in substance use disorders over three generations in a nation-wide study ', P L o S One, vol. 12, no. 5, e0177700 . https://doi.org/10.1371/journal.pone.0177700
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0177700
Popis: OBJECTIVE: This nation-wide register-based study investigated how often substance use disorders (SUD) and co-morbid disorders occurred in affected families compared to control families.METHOD: A total of N = 2504 child and adolescent psychiatric participants who were born between 1969 and 1986 and were registered in the Danish Psychiatric Central Research Register (DPCRR) had a mental disorder before the age of 18 and developed SUD at some point during their life-time. In addition, N = 7472 controls without any psychiatric diagnosis before age 18 and matched for age, sex, and residential region were included. Psychiatric diagnoses of the first-degree relatives were also obtained. A family load component was assessed.RESULTS: SUD occurred significantly more often in case families than in control families. SUD risk factors included SUD, depression, anxiety disorders, personality disorders, or conduct disorders in the family. Furthermore, male sex, more recent year of birth, and living in the capital city of Copenhagen were also significantly associated with having SUD. The family load explained 30% of the SUD manifestation in the case-probands. The findings in the total SUD group were mostly replicated in the two major subgroups of pure alcohol or multiple substance use disorders.DISCUSSION: These findings based on a very large and representative dataset provide additional evidence for the strong family aggregation and further risk factors in SUD. The pattern of risk factors is largely the same for the total group of SUD and the major subgroups of pure alcohol and multiple substance use disorders.
Databáze: OpenAIRE
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