Labetalol therapy in patients with systemic hypertension and angina pectoris: effects of combined alpha and beta adrenoceptor blockade
| Autor: | Thierry H. LeJemtel, Stanley Halprin, Marcia P. Poland, Marc Kirschner, Neal Klein, William H. Frishman, Michael Kram, Edmund H. Sonnenblick, Joel A. Strom |
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| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Platelet Aggregation Adrenergic beta-Antagonists Alpha (ethology) Placebo Plasma renin activity Angina Pectoris Angina Drug withdrawal Heart Rate Internal medicine Renin Heart rate medicine Humans Labetalol Adrenergic alpha-Antagonists Aged business.industry Middle Aged medicine.disease Myocardial Contraction Echocardiography Ethanolamines Anesthesia Hypertension Exercise Test Cardiology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American Journal of Cardiology. 48:917-928 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(81)90359-3 |
| Popis: | The effects of oral labetalol, an alpha-beta adrenoceptor blocker, were evaluated in 10 patients with angina pectoris and hypertension. After 3 weeks of placebo, increasing doses of labetalol (300 to 1,200 mg/day) were given over 4 weeks followed by a rapid drug withdrawal phase. The frequency of anginal attacks and exercise tolerance were measured as were noninvasive indexes of left ventricular function (echocardiography, systolic time intervals), plasma renin activity and platelet function (aggregability). Compared with placebo, during labetalol therapy the frequency of anginal attacks was reduced, exercise time increased (from 351.6 ± 56.2 to 463.2 ± 45.2 seconds , P kilopond - meters , p mm Hg (mean ± Standard error of the mean) (p mm Hg (p beats / min (p mm Hg (p mm Hg (P beats / min (p |
| Databáze: | OpenAIRE |
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