Anticoagulant Therapy for Disseminated Intravascular Coagulation After Gastrointestinal Surgery
| Autor: | Takaomi Okawa, Daisuke Hashimoto, Yuji Shibata, Fujio Matsumura, Riichiroh Maruyama, Hirotsugu Kohrogi |
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| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
medicine.medical_specialty Gabexate mesylate Gabexate Thrombomodulin Hemorrhage 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Humans Medicine Survival rate Digestive System Surgical Procedures Disseminated intravascular coagulation business.industry Antithrombin Anticoagulants General Medicine Disseminated Intravascular Coagulation medicine.disease Surgery Oncology Anticoagulant therapy 030220 oncology & carcinogenesis Anticoagulant Agent business Complication circulatory and respiratory physiology medicine.drug |
| Zdroj: | Anticancer Research. 39:25-31 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.13076 |
| Popis: | Many studies about anticoagulant therapy for disseminated intravascular coagulation (DIC) confused gastrointestinal surgery-related DIC with DIC unrelated to a prior operation. Furthermore, the potentially increased risk of bleeding by anticoagulants complicates their use. We carried out a systematic review to describe the efficacy and safety of anticoagulant agents for DIC after gastrointestinal surgery. Several studies have indicated that gabexate mesylate improves DIC score without increasing bleeding events, and that antithrombin is associated with lower mortality of DIC after gastrointestinal surgery. Recombinant thrombomodulin has been the most frequently analyzed anticoagulant agent in this field. DIC score and survival rate were better in patients treated with recombinant thrombomodulin, without increasing bleeding events. In conclusion, anticoagulant therapy may be effective and safe in DIC after gastrointestinal surgery. |
| Databáze: | OpenAIRE |
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