Effects of lithium carbonate on reproductive hormones in healthy men: Relationship with body weight regulation-a pilot study
| Autor: | JoséLuis Martinez, Enma Araujo de Baptista, Trino Baptista, Marcela Burguera, José Luis Burguera, Luis Hernandez, Quilianio Contreras, T. Alastre |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Thyroid Hormones medicine.medical_specialty Hydrocortisone Radioimmunoassay Thyrotropin Lithium Weight Gain Body Mass Index chemistry.chemical_compound Follicle-stimulating hormone Dehydroepiandrosterone sulfate Lithium Carbonate Reference Values Internal medicine medicine Humans Testosterone Gonadal Steroid Hormones Biological Psychiatry Pharmacology Analysis of Variance Estradiol Dehydroepiandrosterone Sulfate business.industry Reproduction Body Weight Reproducibility of Results Luteinizing Hormone Prolactin Skinfold Thickness Endocrinology chemistry Follicle Stimulating Hormone medicine.symptom business Luteinizing hormone Weight gain Hormone medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 21:937-950 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/s0278-5846(97)00090-0 |
| Popis: | 1. To test the hypothesis that lithium-induced body weight gain is related to an unbalance in the reproductive hormones, lithium carbonate (900 mg/day) or placebo was administered to healthy men for 1 month. 2. Body weight, skin folds and the serum levels of thyrotropic hormone, tetraiodothyroxine, prolactin, follicle-stimulating hormone, luteinizing hormone, testosterone (T5), dehydroepiandrosterone sulfate (DHEAS), estradiol (E2), cortisol, the ratios E2/T5 and T5/DHEA-S, and blood lipids were evaluated before and during treatment. 3. Body weight, skin folds, hormones and lipids serum levels were not significantly affected by the treatment with Li. These results agree with previous reports of lack of effects of 1 month-Li administration on appetite and body weight in normal male subjects (Chen et al., 1992), and question the appropriateness of studying Li-induced obesity in healthy volunteers, given the short-term administration and low doses of Li that must be used. |
| Databáze: | OpenAIRE |
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