Infection-related hospitalisation in young adults with systemic lupus erythematosus: data from the National Inpatient Sample
| Autor: | Rashmi Dhital, Monica Guma, Dilli R Poudel, Christina Chambers, Kenneth Kalunian |
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| Rok vydání: | 2023 |
| Předmět: |
Adult
Inpatients Lupus Erythematosus Adolescent Epidemiology Inflammatory and immune system Systemic Lupus General Medicine Pneumonia Hematology Infections Lupus Nephritis Autoimmune Disease United States Hospitalization Young Adult Infectious Diseases Rheumatology Clinical Research Sepsis Humans Infection Pleurisy |
| Zdroj: | Lupus science & medicine, vol 10, iss 1 |
| Popis: | IntroductionCare of young adults with SLE (YA-SLE, 18–24 years) is challenging due to major life transitions co-occurring with chronic healthcare needs. Studies have demonstrated poorer outcomes in the post-transition period. Epidemiological studies focused on serious infection-related hospitalisation (SIH) in YA-SLE are lacking.MethodsWe used National Inpatient Sample from 2010 to 2019 to study the epidemiology and outcomes of SIH for five common infections in SLE, namely sepsis, pneumonia, urinary tract infections, skin and soft tissue infections, and opportunistic infections. For time trends, we extended the dataset to cover 2000–2019. The primary outcome was the rate of SIH in YA-SLE compared with adults (25–44 years) with SLE and with young adults without SLE (YA-no SLE).ResultsFrom 2010 to 2019, we identified 1 720 883 hospital admissions with SLE in patients aged ≥18 years. Rates of SIH were similar in young adults and adults with SLE (15.0% vs 14.5%, p=0.12), but considerably higher than in the YA-no SLE group (4.2%, pDiscussionYA- SLE had similar rates of SIH to adults with SLE. While hospitalised YA-SLE differed sociodemographically from SLE adults and YA-no SLE, only race/ethnicity was associated with SIH in the YA-SLE group. Lupus nephritis and pleuritis were associated with higher SIH in YA-SLE. Among SLE with SIH, increasing trends of sepsis deserve further study. |
| Databáze: | OpenAIRE |
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