Determining the factors affecting dynamic insertion of microneedles into skin
| Autor: | Sahan A. Ranamukhaarachchi, Boris Stoeber |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
integumentary system
Computer science 010401 analytical chemistry High variability Biomedical Engineering Human skin 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences Artificial skin 0104 chemical sciences 3. Good health medicine.anatomical_structure Biomimetics Needles Stratum corneum medicine 0210 nano-technology Molecular Biology Biomedical engineering Mechanical Phenomena Skin |
| Zdroj: | Biomedical microdevices. 21(4) |
| ISSN: | 1572-8781 |
| Popis: | Microneedles are extremely small and minimally-invasive intradermal drug delivery devices that require controlled, accurate, and repeatable insertions into human skin to perform their functions. Due to high variability and elasticity of human skin, dynamic insertion methods are being sought to ensure success in microneedle insertions into the skin passed the tough stratum corneum layer. Dynamic microneedle insertions have not been thoroughly studied to identify and assess the key parameters influencing the skin fracture to date. Here, we have utilized a previously validated artificial mechanical human skin model to identify and evaluate the factors affecting microneedle insertion. It was determined that a microneedle’s velocity at impact against the skin played the most crucial role in successfully inserting microneedle devices of different geometrical features (i.e., tip area) and array size (i.e., number of projections). The findings presented herein will facilitate the development of automated microneedle insertion devices that will enable user-friendly and error-free applications of microneedle technologies for medicine delivery. |
| Databáze: | OpenAIRE |
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