Multiple pharmacological and toxicological investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents
Autor: | Valentina Di Valerio, Giustino Orlando, Luigi Menghini, Amelia Cataldi, Luigi Brunetti, Monica Rapino, Viviana di Giacomo, Sheila Leone, Maurizio Ronci, Annalisa Chiavaroli, Sanda Vladimir-Knežević, Marija Kindl, Lucia Recinella, Claudio Ferrante |
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Rok vydání: | 2019 |
Předmět: |
Migraine Disorders
Apoptosis Tanacetum parthenium Pharmacology Toxicology Neuroprotection Antioxidants Cell Line Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Nutraceutical Downregulation and upregulation Lactate dehydrogenase medicine Animals Gallic acid 030304 developmental biology Cerebral Cortex Wound Healing 0303 health sciences biology Plant Extracts Cortical Spreading Depression Neurotoxicity Salix 04 agricultural and veterinary sciences General Medicine biology.organism_classification medicine.disease 040401 food science Parthenium Neuroprotective Agents chemistry Salix alba Cortical spreading depression Serotonin Proteomic analysis Artemia Food Science |
Zdroj: | Food and Chemical Toxicology. 133:110783 |
ISSN: | 0278-6915 |
Popis: | Migraine is one of the most common neurological disorder, which has long been related to brain serotonin (5-HT) depletion and neuro-inflammation. Despite many treatment options are available, the frequent occurrence of unacceptable adverse effects further supports the research toward nutraceuticals and herbal preparations, among which Tanacetum parthenium and Salix alba showed promising anti-inflammatory and neuro-modulatory activities. The impact of extract treatment on astrocyte viability, spontaneous migration and apoptosis was evaluated. Anti-inflammatory/anti-oxidant effects were investigated on isolated rat cortexes exposed to a neurotoxic stimulus. The lactate dehydrogenase (LDH) release, nitrite levels and 5-HT turnover were evaluated, as well. A proteomic analysis was focused on specific neuronal proteins and a fingerprint analysis was carried out on selected phenolic compounds. Both extracts appeared able to exert in vitro anti-oxidant and anti-apoptotic effects. S. alba and T. parthenium extracts reduced LDH release, nitrite levels and 5-HT turnover induced by neurotoxic stimulus. The downregulation of selected proteins suggest a neurotoxicity, which could be ascribed to an elevated content of gallic acid in both S. alba and T. parthenium extracts. Concluding, both extracts exert neuroprotective effects, although the downregulation of key proteins involved in neuron physiology suggest caution in their use as food supplements. |
Databáze: | OpenAIRE |
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