Anti-neutrophil cytoplasmic antibodies and their clinical significance
| Autor: | Pawinee Rerknimitr, Helen L. Wright, Muanpetch Rachayon, Jongkonnee Wongpiyabovorn, Pongsawat Rodsaward, Tawatchai Deekajorndech, Direkrit Chiewchengchol, Michael W. Beresford, Steven W. Edwards, Supaporn Suwanchote |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis urologic and male genital diseases Antibodies Antineutrophil Cytoplasmic 03 medical and health sciences 0302 clinical medicine Rheumatology Antigen immune system diseases Eosinophilic Humans Medicine cardiovascular diseases skin and connective tissue diseases 030203 arthritis & rheumatology biology business.industry Autoantibody General Medicine medicine.disease respiratory tract diseases Staining 030104 developmental biology biology.protein Antibody business Vasculitis Microscopic polyangiitis Granulomatosis with polyangiitis |
| Zdroj: | CLINICAL RHEUMATOLOGY |
| Popis: | Anti-neutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies that cause systemic vascular inflammation by binding to target antigens of neutrophils. These autoantibodies can be found in serum from patients with systemic small-vessel vasculitis and they are considered as a biomarker for ANCA-associated vasculitis (AAV). A conventional screening test to detect ANCA in the serum is indirect immunofluorescence study, and subsequently confirmed by enzyme-linked immunosorbent assay. A positive staining of ANCA can be classified into three main categories based on the staining patterns: cytoplasmic, perinuclear, and atypical. Patients with granulomatosis with polyangiitis (GPA) mostly have a positive cytoplasmic staining pattern (c-ANCA) whilst a perinuclear pattern (p-ANCA) is more common in microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) patients. Atypical pattern (a-ANCA) is rarely seen in patients with systemic small-vessel vasculitis but it can be found in other conditions. Here, techniques for ANCA detection, ANCA staining patterns and their clinical significances are reviewed. |
| Databáze: | OpenAIRE |
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