Hypocholesterolemic Activity from the Leaf Extracts of Cnidoscolus chayamansa
| Autor: | Héctor G. Lozano-Garza, Azucena Oranday-Cárdenas, Germán Chamorro-Cevallos, Catalina Rivas-Morales, Lylia Miranda-Velasquez, Delia E. Cruz-Vega |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Hypercholesterolemia Reductase law.invention Mice chemistry.chemical_compound law Chlorocebus aethiops Animals Vero Cells chemistry.chemical_classification Mice Inbred BALB C Ethanol biology Traditional medicine Plant Extracts Cholesterol Anticholesteremic Agents Cnidoscolus Euphorbiaceae biology.organism_classification Plant Leaves Enzyme chemistry Phytochemical Biochemistry Chemistry (miscellaneous) HMG-CoA reductase biology.protein Hydroxymethylglutaryl CoA Reductases Phytotherapy Food Science |
| Zdroj: | Plant Foods for Human Nutrition. 65:392-395 |
| ISSN: | 1573-9104 0921-9668 |
| DOI: | 10.1007/s11130-010-0202-4 |
| Popis: | The aim of this study was to determine the hypocholesterolemic activity of Cnidoscolus chayamansa. In an in vivo model, high-cholesterol diet administered to mice Balb/c induced hypercholesterolemia. Three extracts from Cnidoscolus chayamansa (ethanol, methanol and an aqueous extract) were tested on hypercholesterolemic mice. Active extracts were assessed against the in vitro inhibitory activity of the same three extracts on the HMG-CoA reductase enzyme by using Vero cells. The specific chemical groups present in the phytochemical extracts were also determined. Only the aqueous extract (at either doses employed) showed a significant cholesterol reduction (27.9 and 31.1%, for 50 and 100 mg kg(-1), respectively P |
| Databáze: | OpenAIRE |
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