Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilage

Autor:	Nana Nagura, Hiroto Yamaguchi, Hidetoshi Nojiri, Masato Koike, Yoshiyuki Iwase, Sammy Banno, Kei Miyagawa, Hisashi Kurosawa, Hiroaki Kanazawa, Kazuo Kaneko
Rok vydání:	2018
Předmět:	0301 basic medicine Adult Cartilage Articular Male medicine.medical_specialty Aging Adolescent SOD3 SOD1 SOD2 lcsh:Medicine Superoxide dismutase activity Osteoarthritis Osteoarthritis Hip Superoxide dismutase 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Malondialdehyde medicine Humans lcsh:Science Osteoarthritic cartilage Aged 030203 arthritis & rheumatology Aged 80 and over Multidisciplinary biology Chemistry Superoxide Dismutase Cartilage lcsh:R Synovial Membrane Middle Aged Osteoarthritis Knee medicine.disease 030104 developmental biology Endocrinology medicine.anatomical_structure Case-Control Studies biology.protein lcsh:Q Female Reactive Oxygen Species
Zdroj:	PLoS ONE, Vol 13, Iss 9, p e0203944 (2018)
ISSN:	1932-6203
Popis:	Recent studies have shown that superoxide dismutase 1 (SOD1), SOD2, and SOD3 are significantly decreased in human osteoarthritic cartilage. SOD activity is a marker that can be used to comprehensively evaluate the enzymatic capacities of SOD1, SOD2, and SOD3; however, the trend of SOD activity in end-stage osteoarthritic tissues remains unknown. In the present study, we found that SOD activity in end-stage osteoarthritic synovium of the knee was significantly lower than that in control synovium without the influence of age. The SOD activity was significantly lower in the end-stage knee osteoarthritic cartilage than in the control, but a weak negative correlation was observed between aging and SOD activity. However, SOD activity in end-stage hip osteoarthritic cartilage was significantly lower than that in control cartilage without the influence of aging. The relationship between osteoarthritis and SOD activity was stronger than the relationship between aging and SOD activity. These results indicate that direct regulation of SOD activity in joint tissues may lead to suppression of osteoarthritis progression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647ad40ca8aca54d6a50514da4dff578 https://pubmed.ncbi.nlm.nih.gov/30222787 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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