Risk factors for the metabolic syndrome components of hypertension, diabetes mellitus, and dyslipidemia after living donor liver transplantation
| Autor: | Toru Ikegami, Mototsugu Shimokawa, Yoshihiko Maehara, Tomoharu Yoshizumi, Noboru Harada, Yuji Soejima, Kazuki Takeishi, Yohei Mano, Masaki Mori, Takeshi Kurihara, Yukiko Kosai-Fujimoto, Takeo Toshima, Shoichi Inokuchi, Shohei Yoshiya, Shinji Itoh |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Liver transplantation Logistic regression Diabetes Complications Young Adult Postoperative Complications Risk Factors Internal medicine Diabetes mellitus Living Donors Prevalence medicine Humans Aged Dyslipidemias Retrospective Studies Metabolic Syndrome Hepatology business.industry Incidence (epidemiology) Gastroenterology Middle Aged medicine.disease Liver Transplantation Treatment Outcome Hypertension Female Metabolic syndrome Living donor liver transplantation Complication business Dyslipidemia |
| Zdroj: | HPB. 22:511-520 |
| ISSN: | 1365-182X |
| DOI: | 10.1016/j.hpb.2019.08.008 |
| Popis: | Metabolic syndrome (MS) is the most common long-term complication after liver transplantation, and it has been increasing in incidence. The aim of this study was to clarify the risk factors for each MS component -hypertension, diabetes mellitus, and dyslipidemia-after living-donor liver transplantation (LDLT), including characteristics of living-donors.Data related to clinicopathological parameters including MS components in 461 consecutive patients who underwent LDLT were analyzed retrospectively.Prevalence of all MS components (hypertension, diabetes mellitus, and dyslipidemia) increased from 9.3%, 16.5%, and 7.2% before LDLT to 44.9%, 45.3%, and 50.8% after LDLT, respectively. By multivariate logistic regression analysis, the three factors, cyclosporine use (OR 2.086, P = 0.001), recipient age (OR 1.036, P = 0.001), and BMI (OR 1.072, P = 0.026) were independent predictors for post-LDLT hypertension. Next, the three factors, male recipient (OR 2.471, P 0.001), recipient age (OR 1.039, P = 0.002), and donor BMI (OR 1.124, P = 0.012) were independent for post-LDLT diabetes mellitus. The four factors, cyclosporine use (OR 2.015, P = 0.001), prolonged prednisolone use (OR 1.928, P = 0.002), recipient age (OR 1.019, P = 0.037), and GRWR (OR 0.316, P = 0.037) were independent for post-LDLT dyslipidemia as well.Not only recipient-related factors but also donor-related factors were independently associated with each targeted post-LDLT MS component. |
| Databáze: | OpenAIRE |
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