The role of procalcitonin as a biomarker for acute pulmonary exacerbation in subjects with cystic fibrosis and non-cystic fibrosis bronchiectasis
| Autor: | MAMMADOV, Firuz, OLGUN YILDIZELI, Sehnaz, KOCAKAYA, Derya, ARIKAN, Huseyin, ÇINAR, Caner, ERYUKSEL, Emel, CEYHAN, Berrin |
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| Přispěvatelé: | Mammadov F., Olgun Yildizel S., Kocakaya D., ARIKAN H., Cinar C., Eryuksel E., CEYHAN B. |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
PATHOPHYSIOLOGY
Temel Tıp Bilimleri Medicine (miscellaneous) Assessment and Diagnosis Sağlık Bilimleri Temel Bilgi ve Beceriler Genel Tıp Fundamental Medical Sciences THERAPY Clinical Medicine (MED) Cystic fibrosis C-reactive protein TIP GENEL & DAHİLİ MARKERS SERUM PROCALCITONIN Cystic fibrosis Bronchiectasis Exacerbation Infection Procalcitonin C-reactive protein Health Sciences Internal Medicine Klinik Tıp (MED) ADULT PATIENTS Aile Sağlığı MEDICINE GENERAL & INTERNAL Dahiliye Patofizyoloji Klinik Tıp GUIDANCE Fundamentals and Skills Exacerbation General Medicine CLINICAL MEDICINE Değerlendirme ve Teşhis Tıp Bronchiectasis INFECTIONS General Health Professions Medicine Tıp (çeşitli) Family Practice Infection Procalcitonin Genel Sağlık Meslekleri |
| Zdroj: | Volume: 35, Issue: 2 164-171 Marmara Medical Journal |
| ISSN: | 1019-1941 1309-9469 |
| Popis: | Objective: Patients with cystic fibrosis (CF) and non-CF bronchiectasis are prone to exacerbations of pulmonary infections. C-reactiveprotein (CRP) and procalcitonin (PCT) are inflammatory markers. The aim of this study is to evaluate the role of CRP and PCT onexacerbations of CF and non-CF bronchiectasis.Patients and Methods: The medical records of 18 CF (52 hospitalizations) and 20 non-CF bronchiectasis patients (51 hospitalizations)were reviewed retrospectively. CRP, PCT levels and, white blood cell (WBC) counts on admission and follow-up were evaluated.Results: C-reactive protein levels correlated with PCT levels on admission in all patients. Baseline PCT levels were markedly higher(>0.5µg/L) in 12% of CF and 10% of non-CF bronchiectasis patients, however, baseline CRP values were markedly higher (>5mg/L)in 96% of CF and non-CF bronchiectasis patients (p=0.760 and p=0.100, respectively). Baseline CRP and PCT levels were positivelycorrelated with hospitalization length (r=0.501, p=0.001 and r=0.289, p=0.04, respectively) in CF patients, but not in non-CFbronchiectasis.Conclusion: Our study shows the potential utility of these biomarkers to determine the severity of the exacerbation particularlypredicting hospitalization length in CF patients. Both biomarkers could be able to guide antibiotic treatment of infective exacerbationsin CF and non-CF bronchiectasis patients |
| Databáze: | OpenAIRE |
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