Choline acetyltransferase activity and striatal dopamine receptors in Parkinson's disease in relation to cognitive impairment
| Autor: | Juha O. Rinne, Matias Röyttä, Päivi Marjamäki, Hans Helenius, P. Lönnberg, Petri M. Mattila |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein E4 Caudate nucleus Prefrontal Cortex Hippocampus Choline O-Acetyltransferase Receptors Dopamine Pathology and Forensic Medicine Cellular and Molecular Neuroscience Apolipoproteins E Alzheimer Disease Internal medicine Dopamine receptor D2 medicine Humans Prefrontal cortex Aged Neurons Temporal cortex Receptors Dopamine D2 business.industry Receptors Dopamine D1 Putamen Parkinson Disease Choline acetyltransferase Temporal Lobe Neostriatum Endocrinology Dopamine receptor Female Lewy Bodies Neurology (clinical) Caudate Nucleus Cognition Disorders business |
| Zdroj: | Acta Neuropathologica. 102:160-166 |
| ISSN: | 1432-0533 0001-6322 |
| Popis: | Brain tissue from 44 patients with Parkinson's disease (PD) and 36 age-matched controls was examined for choline acetyltransferase (ChAT) activity, and for densities of D1 and D2 dopamine receptors. Brain samples were examined for Alzheimer' disease (AD) type changes and for Lewy bodies (LBs), and for apolipoprotein E genotype. Patients were evaluated for the stage of cognitive impairment using Reisberg's global deterioration scale. ChAT activity in PD was reduced in all brain areas examined, being 51% of the control mean in the hippocampus (P |
| Databáze: | OpenAIRE |
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