Effects of influenza plus pneumococcal conjugate vaccination versus influenza vaccination alone in preventing respiratory tract infections in children

Autor: Elisabeth A. M. Sanders, Anton M. van Loon, Arno W. Hoes, Eelko Hak, Angelique G S C Jansen
Přispěvatelé: Methods in Medicines evaluation & Outcomes research (M2O)
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Male
Antibiotics
Placebo-controlled study
TIV+plac
Influenza and placebo vaccination
AOM
Acute otitis media
medicine.disease_cause
law.invention
HBV+plac
Hepatitis B virus and placebo vaccination
Cohort Studies
Pneumococcal Vaccines
Randomized controlled trial
law
TIV+PCV7
Influenza and heptavalent pneumococcal conjugate vaccination
Child
Respiratory Tract Infections
Netherlands
Vaccines
Respiratory tract infections
Incidence (epidemiology)
Incidence
Vaccination
Influenza Vaccines
Child
Preschool
Acute Disease
Combination
Drug Therapy
Combination
Female
Seasons
GP
General practitioner
medicine.medical_specialty
medicine.drug_class
RTI
Respiratory tract infection
Placebo
Article
Double-Blind Method
Drug Therapy
Internal medicine
Streptococcus pneumoniae
medicine
Humans
Preschool
Conjugate
Vaccines
Conjugate
business.industry
CI
Confidence interval
Infant
Otitis Media
Pediatrics
Perinatology and Child Health
Immunology
PCR
Polymerase chain reaction
business
Zdroj: The Journal of Pediatrics
The Journal of Pediatrics, 153(6), 764-770.e2. MOSBY-ELSEVIER
ISSN: 0022-3476
Popis: OBJECTIVE: To evaluate the effects of influenza vaccination with or without heptavalent pneumococcal conjugate vaccination on respiratory tract infections (RTIs) in children.STUDY DESIGN: This was a randomized, double-blind, placebo-controlled trial comprising 579 children age 18 to 72 months with a previous history of physician-diagnosed RTI, recruited between 2003 and 2005. The children were assigned to 2 doses of parenteral inactivated trivalent subunit influenza plus heptavalent pneumococcal conjugate vaccination (TIV+PCV7), influenza plus placebo vaccination (TIV+plac), or control hepatitis B virus vaccination plus placebo (HBV+plac). Main outcome measures were febrile RTI and related polymerase chain reaction (PCR)-confirmed influenza, primary care visits, antibiotic prescriptions, and acute otitis media (AOM) episodes.RESULTS: During influenza seasons, febrile RTI were reduced by 24% (95% confidence interval [CI] = 1% to 42%) in the TIV+PCV7 group and by 13% (95% CI = -12% to 32%) in the TIV+plac group compared with the control group. The occurrence of PCR-confirmed influenza was reduced by 52% (95% CI = 7% to 75%) in the TIV+PCV7 group and by 51% (95% CI = 3% to 75%) in the TIV+plac group. Episodes of AOM were reduced by 57% (95% CI = 6% to 80%) in the TIV+PCV7 group and by 71% (95% CI = 30% to 88%) in the TIV+plac group. Outside of the influenza seasons, no significant effects of vaccinations were demonstrated on the studied outcomes.CONCLUSIONS: During influenza seasons, influenza vaccination with or without pneumococcal conjugate vaccination substantially reduced cases of confirmed influenza and AOM episodes.
Databáze: OpenAIRE
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