Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition
| Autor: | Julio J. Ochoa, José L. Quiles, José M. Llamas-Elvira, Maurizio Battino, Cesar L. Ramirez-Tortosa, Magdalena López-Frías, Alfonso Varela-López, Francesca Giampieri, Elena Planells, MCarmen Ramirez-Tortosa |
|---|---|
| Přispěvatelé: | [Varela-Lopez, Alfonso] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Biomed Res Ctr, Granada 18100, Spain, [Ochoa, Julio J.] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Biomed Res Ctr, Granada 18100, Spain, [Lopez-Frias, Magdalena] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Biomed Res Ctr, Granada 18100, Spain, [Planells, Elena] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Biomed Res Ctr, Granada 18100, Spain, [Quiles, Jose L.] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Biomed Res Ctr, Granada 18100, Spain, [Llamas-Elvira, Jose M.] Hosp Virgen Las Nieves, Nucl Med Serv, Granada 18014, Spain, [Ramirez-Tortosa, MCarmen] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Biochem & Mol Biol 2, Biomed Res Ctr, Granada 18100, Spain, [Ramirez-Tortosa, Cesar L.] Complejo Hosp Jaen, Dept Pathol, Jaen 23007, Spain, [Giampieri, Francesca] Univ Politecn Marche, Dept Sci Clin Specialist & Odontostomatol, I-60131 Ancona, Italy, [Battino, Maurizio] Univ Politecn Marche, Dept Sci Clin Specialist & Odontostomatol, I-60131 Ancona, Italy, Spanish Ministry of Education and Science, Autonomous Government of Andalusia, University of Granada's, [Varela-López,A, Ochoa,JJ, López-Frías,M, Planells,E, Giampieri,F, Quiles,JL] Institute of Nutrition and Food Technology 'José Mataix Verdú', Department of Physiology, Biomedical Research Center, University of Granada, Granada, Spain. [Llamas-Elvira,JM] Nuclear Medicine Service, Hospital Virgen de las Nieves, Granada, Spain. [Ramirez-Tortosa,MC] Institute of Nutrition and Food Technology 'José Mataix Verdú', Department of Biochemistry and Molecular Biology II, Biomedical Research Center, University of Granada, Granada, Spain. [Ramirez-Tortosa,CL] Department of Pathology, Complejo Hospitalario de Jaén, Jaén, Spain. [Battino,M] Department of Scienze Cliniche Specialistiche ed Odontostomatologiche, Università Politecnica delle Marche,Ancona, Italy. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Eicosapentaenoic acid Antioxidant Acidos grasos omega-3 medicine.medical_treatment Osteoporosis Ubiquinona Parathyroid hormone Antioxidantes medicine.disease_cause Densidad ósea n-3 PUFA Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings] chemistry.chemical_compound Bone Density Aceites de pescado Osteopontina Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Fatty Acids Omega-3 [Medical Subject Headings] Virgin olive oil oxidative stress Femur Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats Wistar [Medical Subject Headings] Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings] Linfocitos b chemistry.chemical_classification Bone mineral Nutrition and Dietetics Estrés oxidativo Fish oil Docosahexaenoic acid Armas antioxidants Suplementos dietéticos dietary fat Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings] Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Eicosanoids::Arachidonic Acids::Isoprostanes::F2-Isoprostanes [Medical Subject Headings] Older-adults Double-strand-breaks Dieta Hormona paratiroidea lcsh:Nutrition. Foods and food supply Polyunsaturated fatty-acids Polyunsaturated fatty acid medicine.medical_specialty Mitochondrial-function Osteoclast differentiation Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Carrier Proteins::Calcium-Binding Proteins::Osteocalcin [Medical Subject Headings] Check Tags::Male [Medical Subject Headings] lcsh:TX341-641 Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings] Biology Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases Metabolic::Osteoporosis [Medical Subject Headings] Article Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Tumor Necrosis Factors::RANK Ligand [Medical Subject Headings] 03 medical and health sciences Fish Oils Chemicals and Drugs::Lipids::Oils::Fish Oils [Medical Subject Headings] Internal medicine Fatty Acids Omega-3 ubiquinone medicine Animals Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes Mononuclear::Lymphocytes [Medical Subject Headings] Rats Wistar Coenzyme Q10 Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density [Medical Subject Headings] Clinical epidemiology Ligando RANK medicine.disease Diet Rats F2-Isoprostanos Osteocalcina Chemicals and Drugs::Hormones Hormone Substitutes and Hormone Antagonists::Hormones::Peptide Hormones::Parathyroid Hormone [Medical Subject Headings] Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings] 030104 developmental biology Endocrinology chemistry Oxidative stress Technology and Food and Beverages::Technology Industry and Agriculture::Manufactured Materials::Weapons [Medical Subject Headings] Dietary Supplements Chemicals and Drugs::Organic Chemicals::Quinones::Benzoquinones::Ubiquinone [Medical Subject Headings] Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Osteopontin [Medical Subject Headings] Lipid Peroxidation Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::DNA [Medical Subject Headings] DNA Damage Food Science |
| Zdroj: | Nutrients, Vol 9, Iss 2, p 176 (2017) Nutrients; Volume 9; Issue 2; Pages: 176 Nutrients Nutrients, 9(2):176 Digibug. Repositorio Institucional de la Universidad de Granada instname |
| ISSN: | 2072-6643 |
| Popis: | During aging, bone mass declines increasing osteoporosis and fracture risks. Oxidative stress has been related to this bone loss, making dietary compounds with antioxidant properties a promising weapon. Male Wistar rats were maintained for 6 or 24 months on diets with fish oil as unique fat source, supplemented or not with coenzyme Q10 (CoQ10), to evaluate the potential of adding this molecule to the n-3 polyunsaturated fatty acid (n-3 PUFA)-based diet for bone mineral density (BMD) preservation. BMD was evaluated in the femur. Serum osteocalcin, osteopontin, receptor activator of nuclear factor-κB ligand, ostroprotegerin, parathyroid hormone, urinary F2-isoprostanes, and lymphocytes DNA strand breaks were also measured. BMD was lower in aged rats fed a diet without CoQ10 respect than their younger counterparts, whereas older animals receiving CoQ10 showed the highest BMD. F2-isoprostanes and DNA strand breaks showed that oxidative stress was higher during aging. Supplementation with CoQ10 prevented oxidative damage to lipid and DNA, in young and old animals, respectively. Reduced oxidative stress associated to CoQ10 supplementation of this n-3 PUFA-rich diet might explain the higher BMD found in aged rats in this group of animals. This work was supported by the Spanish Ministry of Education and Science (AGL2008-01057) and the Autonomous Government of Andalusia (AGR832). A.V.-L. is recipient of a grant for doctors from University of Granada’s own plan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|