A review on the efficacy and safety of iodine-125 seed implantation in unresectable pancreatic cancers
| Autor: | Ting-Ting Gong, Sheng-Nan Jia, Xin Li, Ya-Min Sun, Hui-Jie Wang, Ze-Cheng Yang, Fu-Xing Wen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Percutaneous medicine.medical_treatment Brachytherapy Cryotherapy Apoptosis 030218 nuclear medicine & medical imaging Iodine Radioisotopes 03 medical and health sciences 0302 clinical medicine Pancreatic cancer Cell Line Tumor medicine Animals Humans Radiology Nuclear Medicine and imaging Chemotherapy Radiological and Ultrasound Technology business.industry Dose-Response Relationship Radiation Seed Implantation medicine.disease Prognosis Pancreatic Neoplasms Treatment Outcome Bypass surgery 030220 oncology & carcinogenesis Cancer cell Radiology Patient Safety business |
| Zdroj: | International journal of radiation biology. 96(3) |
| ISSN: | 1362-3095 |
| Popis: | Background: Pancreatic cancers are the common digestive system tumors with poor prognosis and due to its late diagnosis, surgical resection does not remain a viable treatment option in about 80% of patients. Amongst different treatment options, radioactive 125I seed implantation therapy has also emerged as a good alternative in non-resectable pancreatic cancer patients.Purpose: The present review describes the efficacy and safety of iodine-125 seed implantation in unresectable pancreatic cancers in preclinical and clinical studies.Results: In this technique, small radioactive particles are implanted inside the tumor cells to produce the sustain effects. Due to the short radial distance of these radiations, there is a selective and efficient killing of cancer cells without any significant injury to the neighboring cells. Amongst the different methods for implanting 125I seeds in the pancreatic tissues, CT scan or ultrasound-guided percutaneous seed implantation is preferred as it offers shorter operative time, lesser bleeding, early recovery, lesser complications, and low medical costs. The clinical studies have shown that radioactive 125I seed implantation is a good option for the management of local tumor growth, pain palliation, and improvement in the life span of patients suffering from unresectable pancreatic cancer.Conclusion: It may be employed either alone or in combination with cryotherapy, existing chemotherapy, bypass surgery or radiations to achieve the optimal results in these patients. Nevertheless, there is a need to formulate a uniform dose and procedure to achieve homogeneity and develop references for clinical practices. |
| Databáze: | OpenAIRE |
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