Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies
| Autor: | Calies Menard-Katcher, Leigha D Larsen, Glenn T. Furuta, Lisa A. Spencer, Joanne C. Masterson |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Disease outcome Eosinophilic asthma Review 03 medical and health sciences Leukocyte Count 0302 clinical medicine Immune system Eosinophilic Eosinophilia Medicine Homeostasis Humans eosinophil biologics Effector functions lcsh:QH301-705.5 Tissue homeostasis business.industry eosinophilic gastrointestinal diseases General Medicine Eosinophil respiratory system Asthma Enteritis Eosinophils Intestines 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) eosinophil sub-phenotypes Gastritis Immunology business 030215 immunology |
| Zdroj: | Cells, Vol 10, Iss 426, p 426 (2021) Cells |
| ISSN: | 2073-4409 |
| Popis: | Eosinophils are implicated in the pathophysiology of a spectrum of eosinophil-associated diseases, including gastrointestinal eosinophilic diseases (EGIDs). Biologics that target the IL-5 pathway and are intended to ablate eosinophils have proved beneficial in severe eosinophilic asthma and may offer promise in treating some endotypes of EGIDs. However, destructive effector functions of eosinophils are only one side of the coin; eosinophils also play important roles in immune and tissue homeostasis. A growing body of data suggest tissue eosinophils represent a plastic and heterogeneous population of functional sub-phenotypes, shaped by environmental (systemic and local) pressures, which may differentially impact disease outcomes. This may be particularly relevant to the GI tract, wherein the highest density of eosinophils reside in the steady state, resident immune cells are exposed to an especially broad range of external and internal environmental pressures, and greater eosinophil longevity may uniquely enrich for co-expression of eosinophil sub-phenotypes. Here we review the growing evidence for functional sub-phenotypes of intestinal tissue eosinophils, with emphasis on the multifactorial pressures that shape and diversify eosinophil identity and potential targets to inform next-generation eosinophil-targeting strategies designed to restrain inflammatory eosinophil functions while sustaining homeostatic roles. |
| Databáze: | OpenAIRE |
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