Survival impact of treatment delays in surgically managed oropharyngeal cancer and the role of human papillomavirus status
| Autor: | Sophia Sangar, Govind Raghavan, S. Lazaro, Alexander N. Goel, Maie A. St. John, Mariana I. Frangos, Marilene B. Wang, Jennifer L. Long |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Oncology medicine.medical_specialty Disease Time-to-Treatment 03 medical and health sciences 0302 clinical medicine Internal medicine Overall survival Retrospective analysis Humans Medicine 030212 general & internal medicine Human papillomavirus Papillomaviridae Hpv status Aged Retrospective Studies Adjuvant radiotherapy business.industry Papillomavirus Infections Postoperative radiation Cancer Middle Aged medicine.disease Survival Rate Oropharyngeal Neoplasms Socioeconomic Factors Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female business |
| Zdroj: | Head & Neck. 41:1756-1769 |
| ISSN: | 1097-0347 1043-3074 |
| DOI: | 10.1002/hed.25643 |
| Popis: | Background The impact of treatment delays on survival in oropharyngeal cancer and whether the effect varies by human papillomavirus (HPV) status have yet to be defined. Methods Retrospective analysis of the survival impact of time from diagnosis to surgery (DTS), surgery to radiation (SRT), and duration of radiation (RTD) for patients in the National Cancer Database with resected oropharyngeal cancer who underwent adjuvant radiation from 2010 to 2014. Results We identified optimal thresholds of 30, 40, and 51 days for DTS, SRT, and RTD, respectively, with treatment times exceeding these thresholds associated with significantly worse overall survival. Prolonged SRT and RTD were associated with mortality regardless of HPV status, although rising DTS was only predictive among patients with HPV-negative tumors. Conclusions Treatment delays significantly impact survival in oropharyngeal cancer. The consequences of prolonged DTS may be stronger in HPV-negative than HPV-positive disease. These data serve as a foundation for future research and clinical management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text