No evidence of pancreatic autoimmunity among patients with multiple sclerosis
| Autor: | Luis Castaño, Pablo Villoslada, J. Ramón Bilbao, Ainhoa Martín-Pagola |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Multiple Sclerosis endocrine system diseases Population Autoimmunity medicine.disease_cause General Biochemistry Genetics and Molecular Biology History and Philosophy of Science Gene Frequency medicine Humans education Allele frequency Pancreas Alleles Autoantibodies Type 1 diabetes education.field_of_study Immunity Cellular business.industry Glutamate Decarboxylase General Neuroscience Multiple sclerosis Haplotype Histocompatibility Antigens Class I Autoantibody nutritional and metabolic diseases Carboxypeptidase H medicine.disease stomatognathic diseases medicine.anatomical_structure Diabetes Mellitus Type 1 Haplotypes Spain Immunology Female business |
| Zdroj: | Annals of the New York Academy of Sciences. 1037 |
| ISSN: | 0077-8923 |
| Popis: | Although multiple sclerosis (MS) usually appears isolated from other autoimmune disorders, an overlap with type 1 diabetes mellitus (T1DM) has been described in Sardinia, where T1DM-associated haplotype HLA-B18-DR3-DQ2 contributes to MS risk. To determine whether in our population MS patients show signs of pancreatic autoimmunity and share this haplotype, sera from 49 MS patients were tested for GAD, IA2, and CPH autoantibodies, and MICA exon 5 polymorphism was genotyped in 30 patients. Pancreatic autoimmune markers were not present among MS patients, nor was any MICA allele associated with MS. Overall, there is no evidence supporting a T1DM/MS overlap in our population. |
| Databáze: | OpenAIRE |
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