The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies
| Autor: | Emma K. Erickson, Anna S. Warden, R. Adron Harris, R. Dayne Mayfield, Gizelle Robinson |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Neuroimmunomodulation media_common.quotation_subject Alcohol abuse Review Pharmacology Biology Transcriptome 03 medical and health sciences 0302 clinical medicine Neuroimmune system Genetics medicine Animals Humans Calcium Signaling Repurposing media_common Microglia Addiction Toll-Like Receptors Alcohol dependence medicine.disease Alcoholism Drug repositioning 030104 developmental biology medicine.anatomical_structure Astrocytes Molecular Medicine Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Pharmacogenomics. 17:2081-2096 |
| ISSN: | 1744-8042 1462-2416 |
| DOI: | 10.2217/pgs-2016-0062 |
| Popis: | Transcriptome profiling enables discovery of gene networks that are altered in alcoholic brains. This technique has revealed involvement of the brain’s neuroimmune system in regulating alcohol abuse and dependence, and has provided potential therapeutic targets. In this review, we discuss Toll-like-receptor pathways, hypothesized to be key players in many stages of the alcohol addiction cycle. The growing appreciation of the neuroimmune system’s involvement in alcoholism has also led to consideration of crucial roles for glial cells, including astrocytes and microglia, in the brain’s response to alcohol abuse. We discuss current knowledge and hypotheses on the roles that specific neuroimmune cell types may play in addiction. Current strategies for repurposing US FDA-approved drugs for the treatment of alcohol use disorders are also discussed. |
| Databáze: | OpenAIRE |
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