Hydroconductive and silver-impregnated foam dressings: a comparison
Autor: | H N Hoffman, Anna Day, Abdulnaser Alkhalil, Bonnie C. Carney, Kyle W. Monger, Jeffrey W. Shupp, Jenny Zhang, Lauren T. Moffatt |
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Rok vydání: | 2017 |
Předmět: |
Methicillin-Resistant Staphylococcus aureus
0301 basic medicine Silver Nursing (miscellaneous) food.ingredient Bacterial Toxins In Vitro Techniques medicine.disease_cause Microbiology Enterotoxins 03 medical and health sciences 0302 clinical medicine food Animals Medicine Agar In vivo animal model Food science Wound Healing Superantigens integumentary system business.industry Staphylococcal Infections Antimicrobial Bandages Rats 030104 developmental biology Staphylococcus aureus 030220 oncology & carcinogenesis Anti-Infective Agents Local Wound Infection Fundamentals and skills Burns business |
Zdroj: | Journal of Wound Care. 26:S15-S22 |
ISSN: | 2052-2916 0969-0700 |
Popis: | Objective: As the number of commercially available wound dressings is increasing rapidly, it is important for clinicians to understand the strengths and limitations of each and to recognise relationships between wound type and dressing properties to obtain optimal healing results. Our aim is to test the antimicrobial activity of two dressings. Method: A hydroconductive (HC) dressing and a silver-impregnated foam (SIF) dressing were compared for their potential to reduce the levels meticillin-resistant Staphylococcus aureus (MRSA). We also assessed MRSA-derived biologically active components in liquid or agar matrices, simplified models for heavily exuding or dry wounds respectively, and in an in vivo animal model with MRSA infected wounds. Results: In the agar model (dry wounds) both dressings showed a strong reduction in MRSA activities within 24 hours post-application. The antibacterial effects of the SIF dressing were more pronounced in the liquid model, however, at an increasing cytotoxic cost. In agreement with these in vitro results, assessment of dressings using an MRSA-infected wound in an rat model showed a decrease in MRSA which was significant 7 days post-burn and inoculation, with more compromised viability of MRSA. Dressings showed a similar capability to reduced and eliminate toxic shock syndrome toxin (TSST-1) at day 7 post-burn in the animal model but not at day 4, where the SIF dressing was more potent Conclusion: These results confirm the advantages of using silver in reducing bacterial load in wound treatment, except for conditions of highly exuding wounds where the cytotoxic properties of silver may offset these advantages and HC dressing use is more suitable |
Databáze: | OpenAIRE |
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