The concentrations of cephalosporins in tissue fluid of rats with localized infection
| Autor: | I. Polacek |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Tissue fluid medicine.drug_class Cephalosporin Antibiotics Pharmaceutical Science Biology medicine.disease_cause beta-Lactamases Microbiology Cefazolin medicine Cephaloridine Animals Localized infection Pharmacology (medical) Escherichia coli Escherichia coli Infections Cephradine Pharmacology General Medicine Penetration (firestop) Cephalosporins Rats Disease Models Animal Kinetics Cefamandole Extracellular Space After treatment medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 2:69-77 |
| ISSN: | 1099-081X 0142-2782 |
| DOI: | 10.1002/bdd.2510020108 |
| Popis: | Rats implanted with multiperforated subcutaneous plastic capsules were used as a model for study of the penetration of four cephalosporins into sites infected with Escherichia coli. The concentrations of the antibiotics were determined in uninfected and infected cages microbiologically up to 4 h after treatment. All four cephalosporins entered infected capsules faster than the control ones and the peak concentrations were attained 30-60 min earlier. The clearance of the antibiotics from infected capsules was faster than from uninfected ones, probably due to inactivation by microbial beta-lactamase(s). Serum protein binding may account for differences in the penetration rate of cephalosporins, but serum level and serum half-time seem to contribute to their kinetic profile in tissue fluid. |
| Databáze: | OpenAIRE |
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