Effects of inhibitors of the renin-angiotensin system on reducing blood pressure and expression of inflammatory factors in CHD patients: A network meta-analysis
| Autor: | Run-Mei Liu, Xue-Feng Pang, Yun-Feng Xia |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Ramipril
medicine.medical_specialty Time Factors Physiology Clinical Biochemistry Network Meta-Analysis Anti-Inflammatory Agents Angiotensin-Converting Enzyme Inhibitors Blood Pressure Coronary Disease 030204 cardiovascular system & hematology Renin-Angiotensin System 03 medical and health sciences Angiotensin Receptor Antagonists 0302 clinical medicine Internal medicine Renin–angiotensin system medicine Perindopril Humans 030212 general & internal medicine Enalapril Antihypertensive Agents Randomized Controlled Trials as Topic business.industry Cell Biology Candesartan Blood pressure Treatment Outcome Quinapril Cardiology Inflammation Mediators Olmesartan business Biomarkers medicine.drug |
| Zdroj: | Journal of cellular physiology. 234(5) |
| ISSN: | 1097-4652 |
| Popis: | The renin-angiotensin system (RAS) is an ever-evolving endocrine system with considerable checks and balances on the production and catabolism of angiotensin peptides most likely due to the manifold effects of angiotensins. We aimed to explore the effects of different inhibitors of RAS on blood pressure and expression of inflammatory factors in patients with coronary heart disease (CHD). We initially searched PubMed, EMBASE and Cochrane Library electronic databases with nine eligible randomized controlled trials enrolled. Direct and indirect evidence was combined to calculate the weighted mean difference value and draw surface under the cumulative ranking curves. The results demonstrated that, compared with placebo and enalapril, ramipril had a better effect on reducing systolic blood pressure after short-term usage of drugs ( |
| Databáze: | OpenAIRE |
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