Formulation and Evaluation of Sumatriptan Succinate Oral Disintegrating Tablets Using Super Disintegrants

Autor: Lakshmana Rao P, Prasada Rao M, A, Lakshmi Prasanna, G, Sagar Babu, Bhargavi J, N, Praveen
Jazyk: angličtina
Rok vydání: 2019
Předmět:
DOI: 10.5281/zenodo.2629934
Popis: The main objective of this research work is to formulate and evaluate the oral disintegrating tablets of sumatriptan succinate to provide faster relief from pain to migraine sufferers. The formulations were optimized by incorporating varying composition of croscarmellose sodium and treated agar as super disintegrates. All the excipients are tested for compatibility with model drug, which revealed that there was no physical and chemical interaction occurred. The blend of each formulation was evaluated for precompression parameters before compression. The tablets are prepared by direct compression method. All the excipients are tested for compatibility. The thickness, hardness, friability, weight variation, disintegration time, drug content uniformity, dissolution rate study etc. were evaluated for core tablets. The dissolution rate of prepared tablets was studied using 900 ml of phosphate buffer solution, pH 6.8 at 37 ± 0.5°C and 50 rpm. One tablet was used in each test. Samples of dissolution fluid (5 ml) were withdrawn through a filter at different time intervals (2.5, 5, 10, 15 & 20 min) and assayed for drug content at 226 nm. Based on the dissolution test result TA3 formulation (containing 7.5% Treated Agar) was selected as best formulation among all formulations.
{"references":["Rangasamy Manivannan. Oral disintegrating tablets: A future Compaction Publication International Journal of Pharmaceutical Research and Development 2009; 1: 1-10.","https://pubchem.ncbi.nlm.nih.gov/compound/sumatriptan","Mishra DN, Bindal M, Singh SK. Rapidly disintegrating oral tablet of valdecoxib. Indian drug. 2004; 41: 554.","Kaushik D, Dureja H, Saini TR. Mouth dissolving tablets: A review. Indian Drugs.2004; 41: 503-508.","Ansel HC, Popovich NG, Allen LV.Pharmaceutical dosage forms and drug delivery system. B.I. Waverly Pvt. Ltd, New Delhi. 1995; 6:99-154.","Udaykumar.M, A.B.N.Nageswarao, T.V.S VinayKumar, Fast dissolving Tablets: New-fangled Drug Delivery System A Comprehensive review, International Journal of Research in Drug Delivery, 2012, 2(3), Page:15-25.","Lachman L, Liberman H and Kanig J. In: The theory and practice of industrial pharmacy, 3rdedn. Varghese Publishing House, Mumbai 1987.","Yunxia B, Sunada H, Yonezawz Y, DanjoK. Evaluation of rapidly disintegrating tablets prepared by direct compression method. Drug Dev. Ind. Pharm. 1999; 25(5), Page: 571-581.","Patel D, Patel N. Studies in formulation of or odispersible tablets of rofecoxib. Indian J. Pharm. Sci. 2004, Vol.66, Issue .5, Page: 621-625.","Khan S, Kataria P, Nakhat P, Yeole P. Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid disintegrating tablets. AAPS Pharm SciTech. 2007, 8(2), Article.46."]}
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