Modulation of the locomotor response to amphetamine by corticosterone
| Autor: | Pierre Mormède, Josette Dulluc, Martine Cador |
|---|---|
| Přispěvatelé: | Unité mixte de recherche neurobiologie intégrative, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), ProdInra, Migration |
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Male
Receptors Steroid medicine.medical_treatment Dopamine Nucleus Accumbens chemistry.chemical_compound 0302 clinical medicine Corticosterone Reference Values Chronic stress ComputingMilieux_MISCELLANEOUS 0303 health sciences General Neuroscience Dopaminergic Adrenalectomy Circadian Rhythm Modulation [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Glucocorticoid Locomotion medicine.drug medicine.medical_specialty Dextroamphetamine medicine.drug_class Nucleus accumbens Biology Motor Activity General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Receptors Glucocorticoid History and Philosophy of Science Stress Physiological Internal medicine medicine Animals [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Rats Wistar Amphetamine 030304 developmental biology Dose-Response Relationship Drug business.industry Rats Receptors Mineralocorticoid Endocrinology chemistry Mineralocorticoid Exploratory Behavior RAT business 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Neuroscience, Elsevier-International Brain Research Organization, 1993, 56 (4), pp.981-988 HAL |
| ISSN: | 0306-4522 1873-7544 |
| Popis: | In the present experiments, we investigated the influence of chronic modifications of circulating levels of corticosterone on the locomotor response to amphetamine. Different groups of rats were adrenalectomized and implanted subcutaneously with pellets releasing different amounts of corticosterone (0-200 mg). A wide range of corticosterone concentrations was reached in order to saturate selectively either the type I (mineralocorticoid) or the type II (glucocorticoid) corticosteroid receptors. The locomotor response to d-amphetamine (1.5 mg/kg) was studied 10-14 days later. We found that adrenalectomy reduced the response to d-amphetamine by 33% and that a normal response was restored with pellets releasing physiological concentrations of corticosterone (50-mg pellets), and was potentiated in animals with pellets releasing high amounts of corticosterone mimicking chronic stress situations (200-mg pellets). The correlation between plasma corticosterone concentration, locomotor activity following d-amphetamine and thymus weight, which is a reliable indicator of glucocorticoid action, shows that the influence of the locomotor response to d-amphetamine administration is likely to be mediated via a type II receptor. Since the locomotor activating effect of peripheral administration of d-amphetamine has been shown to depend on the integrity of the dopaminergic innervation of the nucleus accumbens, the effect of d-amphetamine at different doses (0, 1, 3, 10 micrograms/microliter) injected directly into the nucleus accumbens was studied. The results demonstrated that removing the circulating corticosterone induced a similar decrease of the locomotor activity elicited by d-amphetamine injection in the nucleus accumbens. This response was restored in animals with the 50- and 200-mg pellets.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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