A prospective multicentre study on sural nerve action potentials in ALS
| Autor: | Anders Fuglsang-Frederiksen, Annick Labarre-Vila, W. Nix, Ian S. Schofield, Rocco Liguori, Kirsten Pugdahl, Birger Johnsen, Mamede de Carvalho, Peter R.W. Fawcett |
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| Přispěvatelé: | Pugdahl K., Fuglsang-Frederiksen A., Johnsen B., de Carvalho M., Fawcett P.R., Labarre-Vila A., Liguori R., Nix W.A., Schofield I.S., Department of Clinical Neurophysiology, Aarhus University Hospital, Department of Neurology, Hospital de Santa Maria, Newcastle General Hospital, Laboratoire d'électromyographie, CHU Grenoble-PRES Université de Grenoble, Department of Neurological Sciences, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), University Clinics Mainz, Roux-Buisson, Nathalie |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Neural Conduction Action Potentials Sural nerve Sensory system Electromyography Nerve conduction velocity MESH: Electromyography 03 medical and health sciences 0302 clinical medicine Sural Nerve MESH: Neural Conduction Physiology (medical) medicine Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Action Potentials MESH: Amyotrophic Lateral Sclerosis Aged 030304 developmental biology MESH: Aged 0303 health sciences MESH: Humans MESH: Middle Aged medicine.diagnostic_test Amyotrophic Lateral Sclerosis Snap MESH: Adult Middle Aged Sensory Systems MESH: Male Surgery Antidromic MESH: Sural Nerve Electrophysiology medicine.anatomical_structure Neurology Anesthesia Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neurology (clinical) Psychology MESH: Female 030217 neurology & neurosurgery Sensory nerve |
| Zdroj: | Clinical Neurophysiology Clinical Neurophysiology, Elsevier, 2008, 119 (5), pp.1106-10. ⟨10.1016/j.clinph.2008.01.010⟩ |
| ISSN: | 1388-2457 |
| Popis: | International audience; OBJECTIVE: To evaluate sensory nerve conduction studies in ALS in a prospective multicentre study involving 7 neurophysiologists from 6 European countries. METHODS: Bilateral sural potentials were obtained in 35 ALS patients and 35 age-matched controls according to a standardised examination protocol using antidromic surface technique. The recordings from the right sural nerve of the controls were used for reference values. A reduction from the mean of controls greater than 2 SDs was considered abnormal. RESULTS: Reduced sensory nerve action potential (SNAP) amplitude or reduced conduction velocity (CV), or both, was found in 6 ALS patients (17%). Decrease in CV was the most frequent finding, and was observed in 8 nerves from 5 patients. Reduced SNAP amplitude was found in 2 nerves from 2 patients. All changes were minor ranging from -2.1 to -3.2 SDs. CONCLUSIONS: This is the first standardised multicentre study on sensory potentials in ALS. It confirms that although normal sensory findings should be expected in the majority of ALS patients, minor abnormalities are not uncommon. SIGNIFICANCE: Mild sensory abnormalities do not necessarily exclude a diagnosis of ALS. |
| Databáze: | OpenAIRE |
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