How Do Kidneys Adapt to a Deficit or Loss in Nephron Number?
| Autor: | Volker Vallon, Hadi Fattah, Anita T. Layton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Single nephron medicine.medical_specialty Physiology 030232 urology & nephrology Compensatory growth (organ) Renal function Nephron Review Biology urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Homeostasis Humans Renal Insufficiency reproductive and urinary physiology Kidney urogenital system Nephrons Adaptation Physiological 030104 developmental biology medicine.anatomical_structure Endocrinology Glomerular Filtration Rate |
| Zdroj: | Physiology (Bethesda) |
| Popis: | A deficit or loss in the number of nephrons, the functional unit of the kidney, can induce compensatory growth and hyperfunction of remaining nephrons. An increase in single nephron glomerular filtration rate (SNGFR) aims to compensate but may be deleterious in the long term. The increase in SNGFR is determined by the dynamics of nephron loss, total remaining GFR, the body’s excretory demand, and the functional capacity to sustain single nephron hyperfunction. |
| Databáze: | OpenAIRE |
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