Identification of haptoglobin as an endogenous inhibitor of prostaglandin H synthase in the cytosol fraction of primary cells from sheep vesicular glands
| Autor: | A.T. Mursagalieva, L.M. Dzhumalieva, A.T. Mevkh, Tattym Shaikenov, R.U. Beisembaeva |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Endogenous regulation Biophysics Endogeny In Vitro Techniques Prostaglandin H synthase Biochemistry Cytosol Structural Biology Genetics Animals Cyclooxygenase Inhibitors Molecular Biology chemistry.chemical_classification Sheep Haptoglobins biology Haptoglobin Seminal Vesicles Cell Biology Enzyme Peroxidases chemistry Sheep vesicular gland Cell culture Enzyme inhibitor biology.protein Glycoprotein Peroxidase |
| Zdroj: | FEBS Letters. 269:125-127 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(90)81135-b |
| Popis: | It was shown that cytosol of primary sheep vesicular gland cells inhibits peroxidase activity of prostaglandin H synthase (PGHS). The degree of the enzyme inactivation depends on cytosol concentration. It was established that cytosol contains glycoprotein haptoglobin that is one of the cytosol basic components responsible for its property to inhibit PGHS. Haptoglobin is supposed to participate in endogenous regulation of PGHS activity in sheep vesicular glands. |
| Databáze: | OpenAIRE |
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