In the Age of Synthetic Biology, Will Antimicrobial Peptides be the Next Generation of Antibiotics?
| Autor: | Philippe Gabant, Félix Jaumaux, Luz P Gómez de Cadiñanos |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.drug_class 030106 microbiology Antimicrobial peptides Antibiotics Computational biology Biology Biochemistry Microbiology bacteriocins antibiotics antimicrobials 03 medical and health sciences Synthetic biology medicine Pharmacology (medical) Natural ecosystem Microbiome General Pharmacology Toxicology and Pharmaceutics lcsh:RM1-950 Rational design Medical practice Antimicrobial lcsh:Therapeutics. Pharmacology 030104 developmental biology Infectious Diseases Perspective synthetic biology |
| Zdroj: | Antibiotics, Vol 9, Iss 484, p 484 (2020) Antibiotics |
| ISSN: | 2079-6382 |
| Popis: | Antibiotics have changed human health and revolutionised medical practice since the Second World War. Today, the use of antibiotics is increasingly limited by the rise of antimicrobial-resistant strains. Additionally, broad-spectrum antibiotic activity is not adapted to maintaining a balanced microbiome essential for human health. Targeted antimicrobials could overcome these two drawbacks. Although the rational design of targeted antimicrobial molecules presents a formidable challenge, in nature, targeted genetically encoded killing molecules are used by microbes in their natural ecosystems. The use of a synthetic biology approach allows the harnessing of these natural functions. In this commentary article we illustrate the potential of applying synthetic biology towards bacteriocins to design a new generation of antimicrobials. |
| Databáze: | OpenAIRE |
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